CORT and SSTR1

Number of citations of the paper that reports this interaction (PMID 9205124)
10

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		CORT	SSTR1
Gene Name		cortistatin	somatostatin receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	G-protein Coupled Receptor Binding Neuropeptide Hormone Activity	Somatostatin Receptor Activity Neuropeptide Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission	Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Cerebellum Development Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Estradiol Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Octreotide Pasireotide
Diseases
GWAS			Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		7 interactors: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	5 interactors: CORT PRMT5 SNTA1 SST SSTR5
Entrez ID		1325	6751
HPRD ID		04150	01673
Ensembl ID		ENSG00000241563	ENSG00000139874
Uniprot IDs		O00230 Q8IUV6	P30872 Q86SW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Estrogen Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Steroid Hormone Stimulus Response To Peptide G-protein Coupled Receptor Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Cell-cell Signaling Response To Estradiol Cellular Response To Organic Cyclic Compound Response To Hormone Cellular Response To Lipid Response To Glucocorticoid Response To Steroid Hormone Response To Corticosteroid Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Nutrient Levels Cerebellum Development Forebrain Development Response To Extracellular Stimulus Metencephalon Development Response To Organic Substance Hindbrain Development Response To Starvation Regulation Of Cell Proliferation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Signal Transduction Brain Development Head Development Multicellular Organismal Reproductive Process Regulation Of Hormone Secretion Signaling Multicellular Organism Reproduction	Synaptic Transmission Regulation Of Vasoconstriction By Circulating Norepinephrine Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Cell-cell Signaling Somatostatin Signaling Pathway Negative Regulation Of Peptidyl-cysteine S-nitrosylation G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Division Hormone-mediated Apoptotic Signaling Pathway Histone H4-R3 Methylation Endothelial Cell Activation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Peptidyl-arginine N-methylation Response To Steroid Hormone Cellular Response To Estradiol Stimulus Regulation Of Cell Cycle Process Histone Arginine Methylation Ventricular Cardiac Muscle Cell Action Potential Peptidyl-arginine Methylation Regulation Of Membrane Repolarization Hyperosmotic Response Cellular Response To Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Cellular Response To Estrogen Stimulus Negative Regulation Of Cell Proliferation Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Cellular Component Movement Positive Regulation Of Cytokinesis Spliceosomal SnRNP Assembly Regulation Of Cardiac Muscle Cell Contraction
Tagcloud ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr2 sstr3 sstr4 sstr5 sstrs stimulating sw480 tcf wnt
Tagcloud (Difference) ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr2 sstr3 sstr4 sstr5 sstrs stimulating sw480 tcf wnt
Tagcloud (Intersection) ?