CORT and GHSR

Number of citations of the paper that reports this interaction (PMID 11227737)
6

Data Source:
HPRD (in vivo)

		CORT	GHSR
Gene Name		cortistatin	growth hormone secretagogue receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Cell Surface Integral Component Of Membrane Neuron Projection Membrane Raft
	Molecular Function	G-protein Coupled Receptor Binding Neuropeptide Hormone Activity	Growth Hormone Secretagogue Receptor Activity G-protein Coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission	G-protein Coupled Receptor Signaling Pathway Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Growth Hormone Secretion Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Height ( 20881960 23563607)
Protein-Protein Interactions		7 interactors: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	2 interactors: CORT GHRL
Entrez ID		1325	2693
HPRD ID		04150	03541
Ensembl ID		ENSG00000241563	ENSG00000121853
Uniprot IDs		O00230 Q8IUV6	Q92847
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Estrogen Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Steroid Hormone Stimulus Response To Peptide G-protein Coupled Receptor Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Cell-cell Signaling Response To Estradiol Cellular Response To Organic Cyclic Compound Response To Hormone Cellular Response To Lipid Response To Glucocorticoid Response To Steroid Hormone Response To Corticosteroid Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Nutrient Levels Cerebellum Development Forebrain Development Response To Extracellular Stimulus Metencephalon Development Response To Organic Substance Hindbrain Development Response To Starvation Regulation Of Cell Proliferation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Signal Transduction Brain Development Head Development Multicellular Organismal Reproductive Process Regulation Of Hormone Secretion Signaling Multicellular Organism Reproduction	Cortisol Secretion Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Growth Hormone Secretion Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Gastric Acid Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Negative Regulation Of Interleukin-1 Beta Production Regulation Of Circadian Sleep/wake Cycle, Sleep Cell-cell Signaling Regulation Of Response To Food Positive Regulation Of Circadian Rhythm Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Rhythm Regulation Of Appetite Regulation Of Interleukin-6 Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Decidualization Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Synapse Assembly Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Peptide Secretion Maternal Placenta Development Regulation Of Interleukin-1 Beta Production Positive Regulation Of Multicellular Organism Growth Acid Secretion Positive Regulation Of Lipid Transport Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Synapse Assembly Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Hormone Secretion Positive Regulation Of Insulin Secretion
Tagcloud ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	aa aspergillus awamori basal broiler chicks cholesterol conversion cpu crude diets digestibility dmd dry fed feed feeding fos fructooligosaccharide hdl igf1r improves lipoprotein matter secretagogue skeletal supplementation supplemented utilization
Tagcloud (Difference) ?		b10 beta2 bioassays cleft clefts congenic corticosteroid dynamical dysmorphogenesis e14 fraser iir juriloff learn logic malformation outline palatal palate palates palatogenesis plasmin plasminogen proposes rules sequester slower tgf urokinase	aa aspergillus awamori basal broiler chicks cholesterol conversion cpu crude diets digestibility dmd dry fed feed feeding fos fructooligosaccharide hdl igf1r improves lipoprotein matter secretagogue skeletal supplementation supplemented utilization
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