CORT and SSTR3

Number of citations of the paper that reports this interaction (PubMedID 9125122)
0

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		CORT	SSTR3
Description		cortistatin	somatostatin receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse	Plasma Membrane Cilium Membrane Neuron Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Signaling Receptor Binding Protein Binding Neuropeptide Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Cell Migration	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Somatostatin Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium
Drugs			Pasireotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68
Diseases
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		7 interacting genes: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	5 interacting genes: CORT GNAI1 LNX1 SST TP53
Entrez ID		1325	6753
HPRD ID		04150	01675
Ensembl ID		ENSG00000241563	ENSG00000278195
Uniprot IDs		O00230 Q8IUV6	P32745
PDB IDs		7S8L 7S8M 7VDL 7VV4 8X8L	8XIQ 8XIR
Enriched GO Terms of Interacting Partners?		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuron Projection Response To Glucocorticoid Response To Corticosteroid Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation Response To Lipid Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Response To Hormone Signal Transduction Plasma Membrane Cellular Response To Estradiol Stimulus Positive Regulation Of Cytokinesis Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Mast Cell Secretagogue Receptor Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Membrane Regulation Of Insulin Secretion Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Hormone-mediated Apoptotic Signaling Pathway Regulation Of Cell Division Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process	Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Disordered Domain Specific Binding Regulation Of Neuroblast Proliferation Gastrulation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Regulation Of Telomere Maintenance Via Telomere Lengthening Neuroblast Proliferation Apoptotic Signaling Pathway Synaptic Signaling Signaling Cell Communication Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Receptor Ligand Activity Hormone Activity Cell-cell Signaling G Protein-coupled Receptor Binding Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Stem Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Centrosome Beta-catenin-ICAT Complex Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Neuron Apoptotic Process Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Negative Regulation Of Nervous System Development Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of Fibroblast Proliferation Lung Induction Regulation Of Telomere Maintenance Neural Precursor Cell Proliferation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development
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