CORT and MRGPRX2

Number of citations of the paper that reports this interaction (PubMedID 12915402)
0

Data Source:
HPRD (in vivo)

		CORT	MRGPRX2
Description		cortistatin	MAS related GPR family member X2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Neuropeptide Binding Mast Cell Secretagogue Receptor Activity
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Cell Migration	Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Pain Sleep Positive Regulation Of Cytokinesis Mast Cell Degranulation Mast Cell Activation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		7 interacting genes: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	1 interacting genes: CORT
Entrez ID		1325	117194
HPRD ID		04150	06247
Ensembl ID		ENSG00000241563	ENSG00000183695
Uniprot IDs		O00230 Q8IUV6	Q96LB1
PDB IDs		7S8L 7S8M 7VDL 7VV4 8X8L	7S8L 7S8M 7S8N 7S8O 7VDH 7VDL 7VDM 7VUY 7VUZ 7VV0 7VV3 7VV4 7VV5 7VV6
Enriched GO Terms of Interacting Partners?		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuron Projection Response To Glucocorticoid Response To Corticosteroid Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation Response To Lipid Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Response To Hormone Signal Transduction Plasma Membrane Cellular Response To Estradiol Stimulus Positive Regulation Of Cytokinesis Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Mast Cell Secretagogue Receptor Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Membrane Regulation Of Insulin Secretion Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Hormone-mediated Apoptotic Signaling Pathway Regulation Of Cell Division Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process	Neuropeptide Hormone Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Receptor Ligand Activity Hormone Activity G Protein-coupled Receptor Binding
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