SSTR1 and SST

Number of citations of the paper that reports this interaction (PubMedID 1346068)
32

Data Source:
HPRD (in vivo)

		SSTR1	SST
Description		somatostatin receptor 1	somatostatin
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space Cytosol Neuronal Cell Body GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding	Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Negative Regulation Of Cell Population Proliferation Cerebellum Development Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Estradiol Stimulus Cellular Response To Leukemia Inhibitory Factor	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Response To Acidic PH Regulation Of Cell Migration Somatostatin Signaling Pathway Response To Amino Acid Response To Steroid Hormone Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands
Drugs		Pasireotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68
Diseases
GWAS		Chromium levels ( 26025379) Coronary artery aneurysm in Kawasaki disease ( 26434682) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)	Pursuit maintenance gain ( 29064472) Skin pigmentation ( 28300201)
Interacting Genes		5 interacting genes: CORT PRMT5 SNTA1 SST SSTR5	6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6751	6750
HPRD ID		01673	08920
Ensembl ID		ENSG00000139874	ENSG00000157005
Uniprot IDs		P30872 Q86SW9	P61278
PDB IDs		8XIO 8XIP	2MI1 7T10 7WIC 7WJ5 7XAT 7XMR 7XMS 7Y27
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Repolarization Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Receptor Ligand Activity Hormone Activity Transmembrane Transporter Binding Protein-containing Complex Action Potential Syntrophin Complex Hormone-mediated Apoptotic Signaling Pathway Hormone-mediated Signaling Pathway Somatostatin Receptor Activity Positive Regulation Of Protein Kinase A Signaling Histone H4R3 Methyltransferase Activity Peptidyl-arginine N-methylation Positive Regulation Of Dopamine Receptor Signaling Pathway Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Response To Steroid Hormone Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Protein Kinase A Signaling Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Protein-arginine N-methyltransferase Activity Golgi Ribbon Formation Endothelial Cell Activation Regulation Of Monoatomic Ion Transmembrane Transport Nitric-oxide Synthase Binding Adenylate Cyclase Binding Methylosome Regulation Of Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission	Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Neuron Projection Hormone-mediated Signaling Pathway G Protein-coupled Receptor Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Glucocorticoid Cellular Response To Lipid Response To Corticosteroid Response To Steroid Hormone Cellular Response To Estradiol Stimulus Response To Lipid Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Response To Hormone Hormone-mediated Apoptotic Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Protein Retention In ER Lumen Positive Regulation Of Long-term Neuronal Synaptic Plasticity Disulfide Oxidoreductase Activity Nuclear Pore Complex Assembly Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Folding In Endoplasmic Reticulum Nuclear Pore Organization Costamere Ribonucleoprotein Granule Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Protein Disulfide Isomerase Activity
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