SSTR1 and SST

Number of citations of the paper that reports this interaction (PMID 1346068)
51

Data Source:
HPRD (in vivo)

		SSTR1	SST
Gene Name		somatostatin receptor 1	somatostatin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Extracellular Region Extracellular Space Neuronal Cell Body
	Molecular Function	Somatostatin Receptor Activity Neuropeptide Binding	Hormone Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Cerebellum Development Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Estradiol Stimulus	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Octreotide Pasireotide	Cysteamine
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		5 interactors: CORT PRMT5 SNTA1 SST SSTR5	6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6751	6750
HPRD ID		01673	08920
Ensembl ID		ENSG00000139874	ENSG00000157005
Uniprot IDs		P30872 Q86SW9	P61278
PDB IDs			1P2W
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Regulation Of Vasoconstriction By Circulating Norepinephrine Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Cell-cell Signaling Somatostatin Signaling Pathway Negative Regulation Of Peptidyl-cysteine S-nitrosylation G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Division Hormone-mediated Apoptotic Signaling Pathway Histone H4-R3 Methylation Endothelial Cell Activation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Peptidyl-arginine N-methylation Response To Steroid Hormone Cellular Response To Estradiol Stimulus Regulation Of Cell Cycle Process Histone Arginine Methylation Ventricular Cardiac Muscle Cell Action Potential Peptidyl-arginine Methylation Regulation Of Membrane Repolarization Hyperosmotic Response Cellular Response To Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Cellular Response To Estrogen Stimulus Negative Regulation Of Cell Proliferation Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Cellular Component Movement Positive Regulation Of Cytokinesis Spliceosomal SnRNP Assembly Regulation Of Cardiac Muscle Cell Contraction	Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction
Tagcloud ?		3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr2 sstr3 sstr4 sstr5 sstrs stimulating sw480 tcf wnt	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Difference) ?		3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr2 sstr3 sstr4 sstr5 sstrs stimulating sw480 tcf wnt	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Intersection) ?