FANCE and FANCA

Number of citations of the paper that reports this interaction (PubMedID 24469828)
31

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		FANCE	FANCA
Description		FA complementation group E	FA complementation group A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Centrosome Cytosol Fanconi Anaemia Nuclear Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Ovarian Follicle Development DNA Repair DNA Damage Response Gene Expression Interstrand Cross-link Repair Homeostasis Of Number Of Cells	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Height ( 28552196) Ovarian cancer ( 30557369) Pulmonary function (smoking interaction) ( 23284291)	Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		8 interacting genes: BRCA2 CHEK1 FANCA FANCC FANCD2 FANCF FANCG HES1	47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		2178	2175
HPRD ID		02943	06186
Ensembl ID		ENSG00000112039	ENSG00000187741
Uniprot IDs		A0A8Q3WL50 A0A8Q3WMB8 Q9HB96	O15360 Q0VAP4
PDB IDs		2ILR 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex DNA Repair DNA Metabolic Process DNA Damage Response Chromatin Cellular Response To Stress Nucleic Acid Metabolic Process Regulation Of CD40 Signaling Pathway Nucleoplasm Nucleobase-containing Compound Metabolic Process DNA Repair Complex Inner Cell Mass Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle Response To Stress Neuronal Stem Cell Population Maintenance Female Gonad Development Regulation Of Regulatory T Cell Differentiation Male Meiotic Nuclear Division Nucleotide-excision Repair Response To Gamma Radiation BRCA2-MAGE-D1 Complex Nucleus Positive Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Mitotic DNA Integrity Checkpoint Signaling Meiotic Nuclear Division Regulation Of T Cell Activation Mitotic Recombination-dependent Replication Fork Processing Nuclear Division Response To Radiation Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Hindbrain Morphogenesis Renal Interstitial Fibroblast Development Histone H3T11 Kinase Activity Regulation Of Lymphocyte Activation	Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus
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