SSR4 and TAFAZZIN

Data Source: HiPPIP (Novel)

		SSR4	TAFAZZIN
Name		signal sequence receptor subunit 4	tafazzin, phospholipid-lysophospholipid transacylase
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Endomembrane System Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane
	Molecular Function	None	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity Transferase Activity Acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	None	Lipid Metabolic Process Phospholipid Metabolic Process Inner Mitochondrial Membrane Organization Cardiolipin Acyl-chain Remodeling Cristae Formation Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		SRP-dependent cotranslational protein targeting to membrane	Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL
Diseases		None	Dilated cardiomyopathy (DCM) Barth syndrome (BTHS) 3-Methylglutaconic aciduria (MGCA)
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		2 novel interactors: PPP1R16B TAFAZZIN	7 novel interactors: CCDC88C OPN1LW RPL10 SLC6A8 SSR4 TRAK2 VBP1
Interacting Genes		5 interacting genes: HECW1 NLGN3 POMP PTEN SSR3	12 interacting genes: BTRC CFTR CHGB CSNK1E GSK3B LATS2 NHERF2 NONO RUNX1 USP14 USP26 YWHAE
Entrez ID		6748	6901
HPRD ID		02101	02316
Ensembl ID		ENSG00000180879	ENSG00000102125
Uniprot IDs		P51571	A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A6XNE1 Q16635
PDB IDs		8B6L	Not available
GO Terms Enriched among Interactors		Rhythmic Synaptic Transmission Presynaptic Membrane Organization Presynaptic Membrane Assembly Positive Regulation Of Excitatory Postsynaptic Potential Social Behavior Membrane Assembly Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synapse Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Cardiolipin Metabolic Process Regulation Of Nervous System Process Central Nervous System Myelin Maintenance Symmetric, GABA-ergic, Inhibitory Synapse Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Cell Projection Organization Adult Behavior Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Membrane Organization Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling Asymmetric, Glutamatergic, Excitatory Synapse Locomotor Rhythm Regulation Of Cell Junction Assembly Cognition Cell Junction Assembly Chemical Synaptic Transmission Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Learning Or Memory Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Glycerolipid Metabolic Process Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Anatomical Structure Morphogenesis Meiotic Spindle Assembly Synapse Maturation Negative Regulation Of Cell Size Maternal Behavior	Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Wnt Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Rhythmic Process Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Negative Regulation Of Protein Catabolic Process Deubiquitinase Activity Negative Regulation Of Protein Metabolic Process Hippo Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Rhythm Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Microtubule Anchoring At Centrosome Creatine:sodium Symporter Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Hippo Signaling Protein Modification Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Proteolysis Non-canonical Wnt Signaling Pathway Negative Regulation Of Metabolic Process