GCA and SRI

Number of citations of the paper that reports this interaction (PubMedID 12804766)
0

Data Source:
HPRD (in vitro, in vivo)

		GCA	SRI
Description		grancalcin	sorcin
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Z Disc T-tubule Vesicle Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Membrane Fusion	Calcium Ion Transport Signal Transduction Negative Regulation Of Heart Rate Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Neutrophil degranulation	Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		15 interacting genes: ABHD11 ATXN1 BPIFA1 C10orf55 CALCOCO2 CSTPP1 GSTO2 LCP1 MAGEA8 PSMB4 RBFOX1 SRI TRAF1 TRAF2 YPEL3	25 interacting genes: ALG2 ANXA11 ANXA7 ATP2A2 CACNA1C CACNA1S CALCOCO2 GCA GRIK1 MORC3 MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 RYR3 SHBG SIGMAR1 SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1
Entrez ID		25801	6717
HPRD ID		06122	01680
Ensembl ID		ENSG00000115271	ENSG00000075142
Uniprot IDs		B7Z322 H7BXD5 P28676	B4DHQ6 P30626
PDB IDs		1F4O 1F4Q 1K94 1K95	1JUO 2JC2 4U8D 4UPG 4USL 5MRA
Enriched GO Terms of Interacting Partners?		Thioesterase Binding	Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Cellular Response To Purine-containing Compound Cellular Response To Caffeine Response To Caffeine Intracellular Signaling Cassette Sarcoplasmic Reticulum Monoatomic Ion Channel Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Response To Alkaloid Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Binding Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Sarcoplasmic Reticulum Membrane Calcium Ion Transport Muscle System Process Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Calcium Ion Transmembrane Transport Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Action Potential Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion L-type Voltage-gated Calcium Channel Complex Response To Metal Ion Regulation Of Muscle Contraction Intracellular Signal Transduction Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Epinephrine Stimulus Calcium Ion Transport Into Cytosol High Voltage-gated Calcium Channel Activity Calmodulin Binding S100 Protein Binding Muscle Contraction Regulation Of Cardiac Muscle Contraction Response To Epinephrine Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Contraction Regulation Of Hydrogen Peroxide Metabolic Process Response To Magnesium Ion
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