ACTR1A

Description		actin related protein 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Cell Cortex Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Vesicle-mediated Transport
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		2 novel interacting genes: CNNM2 DPCD
Interacting Genes		7 interacting genes: CEBPA DCTN1 DCTN4 NUMA1 SNCA SPTBN1 SPTBN2
Entrez ID		10121
HPRD ID		05507
Ensembl ID		ENSG00000138107
Uniprot IDs		A0A384NQ21 B4DXP9 P61163
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cortex Cell Cortex Region Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Microtubule Polymerization Positive Regulation Of Protein Localization To Cell Periphery Spectrin Regulation Of Microtubule Polymerization Or Depolymerization Protein-containing Complex Neuronal Cell Body Cytoskeleton Phospholipid Binding Negative Regulation Of Protein-containing Complex Assembly Spindle Pole Regulation Of Protein Localization To Cell Periphery Dynein Complex Binding Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule Plus-end Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Actin Filament Capping Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Domain Specific Binding Negative Regulation Of Actin Filament Depolymerization Establishment Of Mitotic Spindle Localization Regulation Of Mitotic Spindle Organization Establishment Of Spindle Orientation Tau Protein Binding Microtubule Binding Synapse Organization Regulation Of Microtubule-based Process Negative Regulation Of Actin Filament Polymerization Establishment Of Organelle Localization Regulation Of Actin Filament Depolymerization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Establishment Of Spindle Localization Tubulin Binding Spindle Localization Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Response To Desipramine Negative Regulation Of Norepinephrine Uptake
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