SPRR3 and EVPL

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
HPRD (in vivo)

		SPRR3	EVPL
Description		small proline rich protein 3	envoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm Extracellular Exosome	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Structural Molecule Activity Protein Binding	Structural Molecule Activity Cadherin Binding
	Biological Process	Epidermis Development Keratinocyte Differentiation Keratinization Wound Healing	Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Inflammatory skin disease ( 25574825)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		3 interacting genes: EVPL IVL LORICRIN	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		6707	2125
HPRD ID		01652	03352
Ensembl ID		ENSG00000163209	ENSG00000167880
Uniprot IDs		Q9UBC9	B7ZLH8 K7EKI0 Q92817
PDB IDs			4QMD
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Keratinization Keratinocyte Differentiation Epidermal Cell Differentiation Epithelial Cell Differentiation Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Modification Process Regulation Of Antibacterial Peptide Production Regulation Of Antimicrobial Humoral Response Cell Differentiation Response To UV-B Cellular Developmental Process Desmosome Protein Metabolic Process Regulation Of Humoral Immune Response Intermediate Filament Cytoskeleton Cytoskeleton Organization Structural Constituent Of Skin Epidermis Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process	Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
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