SIGLEC1 and SPN

Number of citations of the paper that reports this interaction (PubMedID 11238599)
0

Data Source:
HPRD (in vivo)

		SIGLEC1	SPN
Description		sialic acid binding Ig like lectin 1	sialophorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Late Endosome Plasma Membrane Membrane	Uropod Basement Membrane Extracellular Space Nucleus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Cell Projection Extracellular Exosome
	Molecular Function	Carbohydrate Binding Virion Binding	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Clathrin-dependent Endocytosis Of Virus By Host Cell Cell-cell Adhesion	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Leukocyte Tethering Or Rolling Apoptotic Signaling Pathway Regulation Of T Cell Migration Positive Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall Basigin interactions
Drugs		Beta-D-Glucose N-acetyl-alpha-neuraminic acid
Diseases
GWAS		IgM levels ( 28628107) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Reticulocyte fraction of red cells ( 32888494) Visceral fat ( 30942860)
Interacting Genes		3 interacting genes: MUC1 SPN TNR	18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2
Entrez ID		6614	6693
HPRD ID		02854	06770
Ensembl ID		ENSG00000088827	ENSG00000197471
Uniprot IDs		Q9BZZ2	P16150
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Negative Regulation Of Cell-cell Adhesion Regulation Of Type IV Hypersensitivity Tenascin Complex Axon Extension Involved In Regeneration Neuroblast Migration Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Response To Stress Negative Regulation Of Transcription By Competitive Promoter Binding Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Negative Regulation Of Acute Inflammatory Response Regulation Of Cell-cell Adhesion Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Thymic T Cell Selection Negative T Cell Selection Uropod Locomotory Exploration Behavior Neuron Cell-cell Adhesion Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Perineuronal Net T-helper Cell Lineage Commitment Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Tethering Or Rolling Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Lineage Commitment Leukocyte Adhesion To Vascular Endothelial Cell Alpha-beta T Cell Lineage Commitment Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Surface CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Axon Regeneration Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Protozoan T Cell Lineage Commitment T Cell Selection Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Projection Regeneration Negative Regulation Of Axon Extension	Membrane To Membrane Docking Disordered Domain Specific Binding Microvillus Membrane Cell Periphery Regulation Of Protein Catabolic Process Cell-cell Adhesion Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Lymphocyte Migration Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Lymphocyte Activation Leukocyte Migration Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Protein Catabolic Process Uropod Apical Part Of Cell Membrane Docking Layer Formation In Cerebral Cortex Postsynaptic Density, Intracellular Component Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of ERAD Pathway Cell Adhesion Mononuclear Cell Migration Membrane Cell Migration Regulation Of Protein Localization T Cell Activation Leukocyte Activation Establishment Of Apical/basal Cell Polarity Negative Regulation Of Protein Catabolic Process Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of ERAD Pathway Epithelial Cell Development Plasma Membrane Regulation Of Cell Shape Positive Regulation Of Intracellular Transport Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell Activation Cell Motility Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
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