SIGLEC1

Description		sialic acid binding Ig like lectin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Late Endosome Plasma Membrane Membrane
	Molecular Function	Carbohydrate Binding Virion Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Clathrin-dependent Endocytosis Of Virus By Host Cell Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Beta-D-Glucose N-acetyl-alpha-neuraminic acid
Diseases
GWAS		IgM levels ( 28628107) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Reticulocyte fraction of red cells ( 32888494) Visceral fat ( 30942860)
Interacting Genes		3 interacting genes: MUC1 SPN TNR
Entrez ID		6614
HPRD ID		02854
Ensembl ID		ENSG00000088827
Uniprot IDs		Q9BZZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Negative Regulation Of Cell-cell Adhesion Regulation Of Type IV Hypersensitivity Tenascin Complex Axon Extension Involved In Regeneration Neuroblast Migration Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Response To Stress Negative Regulation Of Transcription By Competitive Promoter Binding Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Negative Regulation Of Acute Inflammatory Response Regulation Of Cell-cell Adhesion Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Thymic T Cell Selection Negative T Cell Selection Uropod Locomotory Exploration Behavior Neuron Cell-cell Adhesion Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Perineuronal Net T-helper Cell Lineage Commitment Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Tethering Or Rolling Thymic T Cell Selection CD4-positive, Alpha-beta T Cell Lineage Commitment Leukocyte Adhesion To Vascular Endothelial Cell Alpha-beta T Cell Lineage Commitment Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Surface CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Axon Regeneration Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Protozoan T Cell Lineage Commitment T Cell Selection Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Projection Regeneration Negative Regulation Of Axon Extension
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