SORD and SHBG

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SORD	SHBG
Gene Name		sorbitol dehydrogenase	sex hormone-binding globulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Motile Cilium Mitochondrial Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	L-iditol 2-dehydrogenase Activity Zinc Ion Binding Carbohydrate Binding NAD Binding	Androgen Binding
	Biological Process	Glucose Metabolic Process Sorbitol Catabolic Process Sperm Motility Fructose Biosynthetic Process L-xylitol Catabolic Process L-xylitol Metabolic Process Oxidation-reduction Process	Primary Spermatocyte Growth
Pathways
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
Diseases
GWAS			Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		2 interactors: RELA SHBG	62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		6652	6462
HPRD ID		01679	01646
Ensembl ID			ENSG00000129214
Uniprot IDs		Q00796	B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278
PDB IDs		1PL6 1PL7 1PL8	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Acetaldehyde Metabolic Process Primary Spermatocyte Growth Positive Regulation Of Schwann Cell Differentiation Regulation Of Schwann Cell Differentiation Response To Cobalamin Positive Regulation Of MiRNA Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Nicotine Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Response To Muramyl Dipeptide Response To UV-B Membrane Protein Intracellular Domain Proteolysis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Interleukin-6 Positive Regulation Of Chondrocyte Differentiation Response To Interleukin-6 Membrane Protein Proteolysis Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Response To Morphine Response To Nicotine Cellular Response To Alkaloid Positive Regulation Of Cartilage Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Response To Progesterone Positive Regulation Of Gliogenesis Toll-like Receptor 5 Signaling Pathway Cellular Defense Response Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cellular Response To Hydrogen Peroxide Toll-like Receptor 9 Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Chondrocyte Differentiation MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Glial Cell Differentiation Cellular Aldehyde Metabolic Process Positive Regulation Of Type I Interferon Production	Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process
Tagcloud ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mme mpi numbered phosphorylase provisionally sme sorbitol ssod	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Difference) ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mme mpi numbered phosphorylase provisionally sme sorbitol ssod	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Intersection) ?