SORD

Description		sorbitol dehydrogenase
Image
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Cytosol Cilium Membrane Motile Cilium Mitochondrial Membrane Cell Projection Extracellular Exosome
	Molecular Function	(R,R)-butanediol Dehydrogenase Activity L-iditol 2-dehydrogenase (NAD+) Activity Alcohol Dehydrogenase (NAD+) Activity Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Carbohydrate Binding Identical Protein Binding D-xylulose Reductase Activity Metal Ion Binding D-sorbitol Dehydrogenase (acceptor) Activity Ribitol 2-dehydrogenase (NAD+) Activity NAD Binding
	Biological Process	Glucose Metabolic Process Sorbitol Metabolic Process Sorbitol Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Flagellated Sperm Motility Fructose Biosynthetic Process Xylitol Catabolic Process Xylitol Metabolic Process
Pathways		Fructose biosynthesis Formation of xylulose-5-phosphate
Drugs		NADH Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
Diseases
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476)
Novel Interacting Genes		1 novel interacting genes: KRT5
Interacting Genes		3 interacting genes: CEBPA RELA SHBG
Entrez ID		6652
HPRD ID		01679
Ensembl ID		ENSG00000140263
Uniprot IDs		Q00796
PDB IDs		1PL6 1PL7 1PL8
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding Response To Tumor Necrosis Factor Histone Deacetylase Binding Cellular Response To Tumor Necrosis Factor Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 Liver Development C/EBP Complex Intermediate Filament Polymerization Intermediate Filament Polymerization Or Depolymerization NF-kappaB P50/p65 Complex CHOP-C/EBP Complex Response To Ketone DNA-binding Transcription Factor Binding White Fat Cell Proliferation Response To Steroid Hormone Response To Mechanical Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Cobalamin Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Postsynapse To Nucleus Signaling Pathway Androgen Binding Transcription Cis-regulatory Region Binding Gland Development Response To Phenylpropanoid Ankyrin Repeat Binding Cellular Response To Peptidoglycan Response To Xenobiotic Stimulus Fat Cell Proliferation Cellular Response To Nicotine Urea Metabolic Process HMG Box Domain Binding Protein-containing Complex Binding Regulation Of Protein Catabolic Process Urea Cycle STAT Family Protein Binding Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipoteichoic Acid Response To Peptidoglycan Phosphate Ion Binding Defense Response To Tumor Cell General Transcription Initiation Factor Binding
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