RERE and NR2E1

Number of citations of the paper that reports this interaction (PMID 16481466)
26

Data Source:
BioGRID (pull down)

		RERE	NR2E1
Gene Name		arginine-glutamic acid dipeptide (RE) repeats	nuclear receptor subfamily 2, group E, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus	Nucleoplasm
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Poly-glutamine Tract Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Steroid Hormone Receptor Activity Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated NLS-bearing Protein Import Into Nucleus Multicellular Organismal Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Aggressive Behavior Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Visual Perception Glial Cell Migration Gene Expression Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Anterior Commissure Morphogenesis Extracellular Matrix Organization Somatic Stem Cell Maintenance Social Behavior Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bone mineral density ( 22504420) Vertical cup-disc ratio ( 20548946) Vitiligo ( 20410501)
Protein-Protein Interactions		20 interactors: ALG13 ATN1 CBFA2T2 ECM1 EFEMP1 EFEMP2 EHMT2 HIST2H3C KAT6A KRTAP4-12 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 TRIM22 TRIP6 ZMYND8	6 interactors: ATN1 BCL11A ERBB2IP KDM1A NSD1 RERE
Entrez ID		473	7101
HPRD ID		05566	07230
Ensembl ID		ENSG00000142599	ENSG00000112333
Uniprot IDs		B1AKN3 Q9P2R6	B6ZGT9 Q6ZMP8 Q9Y466
PDB IDs		2YQK
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression DNA Methylation On Cytosine Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transcription, DNA-templated RNA Biosynthetic Process Amygdala Development RNA Metabolic Process DNA Methylation Somatic Stem Cell Maintenance Response To Stress Negative Regulation Of Cell Differentiation Cellular Macromolecule Biosynthetic Process DNA Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity DNA Methylation On Cytosine Within A CG Sequence Blood Coagulation Hemostasis Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Angiogenesis Regulation Of Cell Differentiation Peptidyl-amino Acid Modification Phosphatidylserine Biosynthetic Process Regulation Of Timing Of Neuron Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Chromatin Modification Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Basal Protein Localization Chromatin Organization Negative Regulation Of Cellular Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Homooligomerization Chromosome Organization Multicellular Organismal Development Negative Regulation Of Collateral Sprouting Peptidyl-lysine Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Protein Oligomerization Positive Regulation Of Megakaryocyte Differentiation Histone H3-K36 Methylation Leukocyte Differentiation Positive Regulation Of Collateral Sprouting Positive Regulation Of Hormone Biosynthetic Process Maintenance Of Cell Polarity Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Developmental Process
Tagcloud ?		antagonism caudal downregulating e8 ectopic embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate	carcinogenesis cdkn1a doxorubicin druggable ectopic enhancement escape exact oncogene orphan overcoming perform potently premalignant prevent promoted prostate prostatic pten rasg12v repression senescence sirt1 suppressing tlx transactivation triggered tumour tumourigenesis
Tagcloud (Difference) ?		antagonism caudal downregulating e8 embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate	carcinogenesis cdkn1a doxorubicin druggable enhancement escape exact oncogene orphan overcoming perform potently premalignant prevent promoted prostate prostatic pten rasg12v repression senescence sirt1 suppressing tlx transactivation triggered tumour tumourigenesis
Tagcloud (Intersection) ?		ectopic