BNIP2 and HSPA1B

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		BNIP2	HSPA1B
Description		BCL2 interacting protein 2	heat shock protein family A (Hsp70) member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nucleolus Cytoplasm Centriole Cytosol Spindle Pole Centrosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	GTPase Activator Activity Calcium Ion Binding Protein Binding	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Unfolded Protein Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Blastocyst Development Apoptotic Process Centrosome Cycle Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Cell Differentiation Response To Oxygen-glucose Deprivation	MRNA Catabolic Process Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Myogenesis Myogenesis	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Eosinophilic esophagitis ( 29904099) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908)
Interacting Genes		56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A	25 interacting genes: AIFM1 BAG1 BAG4 BNIP2 CEBPA DNMBP F2RL1 FAF1 FTCD HSPBP1 MYBPC2 NEDD8 PGAM5 SGCG SNCA ST13 STUB1 SUMO4 TGM2 TOMM70 TRIM38 TTN UBQLN2 YWHAB YWHAZ
Entrez ID		663	3304
HPRD ID		04481	06784
Ensembl ID		ENSG00000140299	ENSG00000204388
Uniprot IDs		H7C096 Q12982	A8K5I0 P0DMV8 P0DMV9
PDB IDs			1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R
Enriched GO Terms of Interacting Partners?		Protein Binding Endoplasmic Reticulum Membrane Regulation Of Growth Regulation Of Cell Growth Negative Regulation Of Endocytic Recycling Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Endoplasmic Reticulum Somite Specification Positive Regulation Of Growth Positive Regulation Of Cell Growth Regulation Of Vesicle Fusion Chromaffin Granule Membrane Mitochondrial Membrane	Ubiquitin Protein Ligase Binding Adenyl-nucleotide Exchange Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Protein Folding Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Protein Domain Specific Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization Phosphoserine Residue Binding Cytosol Protein Sequestering Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Hsp70 Protein Binding Positive Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Stability Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Protein Tag Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Regulator Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Alkaloid Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cell Communication Regulation Of Signaling Dopamine Transport Perinuclear Region Of Cytoplasm Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process M Band Regulation Of ERAD Pathway Negative Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
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