BNIP2 and RASGRP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BNIP2	RASGRP4
Description		BCL2 interacting protein 2	RAS guanyl releasing protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nucleolus Cytoplasm Centriole Cytosol Spindle Pole Centrosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Calcium Ion Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Blastocyst Development Apoptotic Process Centrosome Cycle Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Cell Differentiation Response To Oxygen-glucose Deprivation	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response
Pathways		Myogenesis Myogenesis	FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A	6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		663	115727
HPRD ID		04481	09540
Ensembl ID		ENSG00000140299	ENSG00000171777
Uniprot IDs		H7C096 Q12982	Q8TDF6
PDB IDs			6AXG
Enriched GO Terms of Interacting Partners?		Protein Binding Endoplasmic Reticulum Membrane Regulation Of Growth Regulation Of Cell Growth Negative Regulation Of Endocytic Recycling Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Endoplasmic Reticulum Somite Specification Positive Regulation Of Growth Positive Regulation Of Cell Growth Regulation Of Vesicle Fusion Chromaffin Granule Membrane Mitochondrial Membrane	Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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