SNAPC2 and MBD1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		SNAPC2	MBD1
Description		small nuclear RNA activating complex polypeptide 2	methyl-CpG binding domain protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck
	Molecular Function	RNA Polymerase II General Transcription Initiation Factor Activity	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Transcription By RNA Polymerase III SnRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		HDL cholesterol ( 26160806) LDL cholesterol ( 26160806)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		3 interacting genes: MBD1 SNAPC4 TBP	47 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT HUNK JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TIAM1 TNC ZNF384 ZNF512B
Entrez ID		6618	4152
HPRD ID		05464	01133
Ensembl ID		ENSG00000104976	ENSG00000141644
Uniprot IDs		Q13487	A0A994J7H0 A8K654 B4DI41 B4DUR3 Q9UIS9
PDB IDs			1D9N 1IG4 4D4W 5W9Q 6D1T
Enriched GO Terms of Interacting Partners?		RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase II Transcription By RNA Polymerase III RNA Polymerase II General Transcription Initiation Factor Activity DNA-templated Transcription DNA Binding Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SnRNA-activating Protein Complex Double-stranded Methylated DNA Binding RNA Polymerase Transcription Factor SL1 Complex TFIIB-class Transcription Factor Binding Transcription Factor TFIIA Complex Unmethylated CpG Binding Macromolecule Biosynthetic Process RNA Metabolic Process SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding Male Pronucleus Aryl Hydrocarbon Receptor Binding Pronucleus RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Female Germ Cell Nucleus SnRNA Transcription Core Promoter Sequence-specific DNA Binding Male Gamete Generation Spermatogenesis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Gamete Generation Nucleic Acid Metabolic Process Methyl-CpG Binding Acrosome Assembly Transcription Factor TFIID Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process SnRNA Metabolic Process RNA Polymerase II Preinitiation Complex Assembly Male Germ Cell Nucleus Constitutive Heterochromatin Formation MRNA Transcription Euchromatin Transcription Preinitiation Complex Assembly Developmental Process Involved In Reproduction	Heteromeric SMAD Protein Complex SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ossification DEAD/H-box RNA Helicase Binding Positive Regulation Of Developmental Process Transcription Corepressor Activity Kidney Epithelium Development Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Nucleus Regulation Of Cell Population Proliferation Regulation Of MiRNA Metabolic Process Ureteric Bud Development SUMO Ligase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ossification Nucleoplasm Mesonephric Tubule Development Mesonephric Epithelium Development Epigenetic Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Auditory Receptor Cell Fate Commitment Osteoblast Fate Commitment SUMO Transferase Activity
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