STAB2

Gene Name		stabilin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Low-density Lipoprotein Receptor Activity Scavenger Receptor Activity Protein Binding Hyaluronic Acid Binding Protein Disulfide Oxidoreductase Activity Low-density Lipoprotein Particle Binding
	Biological Process	Angiogenesis Carbohydrate Metabolic Process Endocytosis Receptor-mediated Endocytosis Cell Adhesion Pathogenesis Regulation Of Gene Expression Regulation Of Blood Coagulation Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Defense Response To Bacterium Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Scavenging by Class H Receptors MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Coronary restenosis ( 21878436) vWF and FVIII levels ( 21810271)
Protein-protein Interactions		2 interactors: SUMO1 SUMO3
Entrez ID		55576
HPRD ID		10542
Ensembl ID		ENSG00000136011
Uniprot IDs		Q8WWQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Localization To Nucleus Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Peptidyl-lysine Modification Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process PML Body Organization Protein Localization To Nuclear Pore Protein Localization To Organelle Protein Localization To Nuclear Envelope Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Peptidyl-amino Acid Modification Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Localization Negative Regulation Of DNA Binding Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Binding Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Binding Regulation Of Protein Metabolic Process Palate Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleus Organization Interferon-gamma-mediated Signaling Pathway Cellular Localization Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Response To Interferon-gamma Positive Regulation Of Protein Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Regulation Of Binding
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