CHTOP and APOBEC3C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHTOP	APOBEC3C
Description		chromatin target of PRMT1	apolipoprotein B mRNA editing enzyme catalytic subunit 3C
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck	P-body Nucleus Cytoplasm
	Molecular Function	RNA Binding Protein Binding Methyl-CpG Binding	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development Chromatin Remodeling MRNA Export From Nucleus Positive Regulation Of ATP-dependent Activity MRNA Transport Positive Regulation Of Helicase Activity	Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Defense Response To Symbiont
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		11 interacting genes: APOBEC3C APP CEBPA GSK3A KHDRBS2 PHLDB3 RBM3 SMN1 SMN2 SNRPA SRPK2	30 interacting genes: ARIH2 CHTOP CUL5 FBXO7 HHEX HNRNPK MYO10 NXF1 PCBP2 PCBP3 PRPF31 PRR3 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J SF1 SHBG SNRPA SNW1 SRPK2 TRAF3 TRIB3 UBC UNKL ZNF250 ZNF408 ZNF48 ZNF581
Entrez ID		26097	27350
HPRD ID		13163	09671
Ensembl ID		ENSG00000160679	ENSG00000244509
Uniprot IDs		A0A087X1B7 Q9Y3Y2	Q9NRW3
PDB IDs			3VM8 3VOW
Enriched GO Terms of Interacting Partners?		RNA Binding Spliceosomal Complex Assembly Positive Regulation Of Neuron Apoptotic Process RNA Metabolic Process RNA Processing MRNA Processing SMN Complex Gemini Of Cajal Bodies MRNA Metabolic Process Response To Lithium Ion Cellular Response To Lithium Ion Regulation Of MRNA Splicing, Via Spliceosome SMN-Sm Protein Complex Positive Regulation Of Gene Expression DNA-templated Transcription Termination RNA Splicing Regulation Of MRNA Processing Axon Perikaryon Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Nucleic Acid Metabolic Process Cellular Response To Metal Ion Regulation Of RNA Splicing Protein-RNA Complex Assembly Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of UDP-glucose Catabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Cajal Body Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity Response To Metal Ion Lipoprotein Particle	Spliceosomal Complex MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding RNA Splicing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding MRNA Processing Nucleus Positive Regulation Of RNA Splicing RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Metabolic Process Identical Protein Binding Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Viral RNA Genome Replication Nucleobase-containing Compound Metabolic Process Transcription Export Complex Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Protein Binding Regulation Of Gene Expression Catalytic Step 2 Spliceosome Viral Genome Replication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Protein K48-linked Ubiquitination Nuclear Speck Ubiquitin Ligase Complex Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process CGAS/STING Signaling Pathway Ubiquitin-protein Transferase Activity Nucleolus 14-3-3 Protein Binding
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