MTMR9 and GRAMD4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MTMR9	GRAMD4
Name		myotubularin related protein 9	GRAM domain containing 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity	Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation	Apoptotic Process Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Apoptotic Process
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	None
GWAS		Adventurousness ( 30643258 ) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463 ) Brain morphology (MOSTest) ( 32665545 ) Essential hypertension (time to event) ( 32589924 ) Extraversion ( 27918536 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) General factor of neuroticism ( 30867560 ) Processed meat consumption ( 32066663 ) Refractive error ( 32231278 ) Retinal vascular caliber ( 21060863 ) Systemic lupus erythematosus ( 26316170 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Urate levels in obese individuals ( 25811787 )
Novel Interactors		1 novel interactors: BLK	1 novel interactors: PKDREJ
Interacting Genes		26 interacting genes: AATK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655	13 interacting genes: APP CATSPERT CCDC146 EXOC8 FAM9B GADD45G MTMR9 NTAQ1 PLEKHF2 RBL2 SH2D4A SMARCD1 TACC2
Entrez ID		66036	23151
HPRD ID		09377	11107
Ensembl ID		ENSG00000104643	ENSG00000075240
Uniprot IDs		Q96QG7	Q6IC98
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Protein Tyrosine Kinase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Neuregulin Receptor Activity Phosphatidylinositol Dephosphorylation Protein Kinase Activity Phospholipid Dephosphorylation Phosphatidylinositol Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Kinase Activity Developmental Maturation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Establishment Of Planar Polarity Protein Tyrosine Phosphatase Activity Phosphatidylinositol Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Dephosphorylation Neuron Maturation Glycerolipid Metabolic Process Protein Binding Establishment Of Planar Polarity Involved In Nephron Morphogenesis Lipid Modification PAS Complex Phospholipid Metabolic Process Cell Maturation	None