MTMR9 and BLK

Data Source: HiPPIP (Novel)

		MTMR9	BLK
Name		myotubularin related protein 9	BLK proto-oncogene, Src family tyrosine kinase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation	Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		None	Fostamatinib Zanubrutinib
Diseases		None	Maturity onset diabetes of the young (MODY)
GWAS		Adventurousness ( 30643258 ) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463 ) Brain morphology (MOSTest) ( 32665545 ) Essential hypertension (time to event) ( 32589924 ) Extraversion ( 27918536 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) General factor of neuroticism ( 30867560 ) Processed meat consumption ( 32066663 ) Refractive error ( 32231278 ) Retinal vascular caliber ( 21060863 ) Systemic lupus erythematosus ( 26316170 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Albumin-globulin ratio ( 29403010 ) Barrett's esophagus ( 27527254 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Brain morphology (MOSTest) ( 32665545 ) Depression ( 33859377 ) Diastolic blood pressure ( 27841878 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Estimated glomerular filtration rate ( 31152163 ) Fasting insulin ( 34059833 ) Fish- and plant-related diet ( 32066663 ) General factor of neuroticism ( 30867560 ) General risk tolerance (MTAG) ( 30643258 ) Immune response to smallpox vaccine (IL-6) ( 22610502 ) Kawasaki disease ( 33106546 33772158 22446961 22446962 ) Neurofibrillary tangles ( 31497858 ) Non-albumin protein levels ( 29403010 ) Number of sexual partners ( 30643258 ) Periodontitis (CDC/AAP) ( 24024966 ) Phosphatidylcholine levels ( 31551469 ) Polymyositis ( 26362759 ) Processed meat consumption ( 32066663 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 21452313 23143596 24390342 19503088 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 33272962 32771030 28714469 26663301 19165918 19838193 19838195 21408207 23053960 23273568 26316170 26502338 27399966 18204098 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic sclerosis ( 31672989 29293537 30572963 ) Systolic blood pressure ( 27618452 27841878 28135244 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: BLK	5 novel interactors: EGR3 FAM167A MTMR9 SPAG11B TFAP2C
Interacting Genes		26 interacting genes: AATK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655	51 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR ERBB2 ERBB3 ERBB4 FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS1 SOCS3 SSBP3 STAP2 STAT3 TDP2 UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774
Entrez ID		66036	640
HPRD ID		09377	01866
Ensembl ID		ENSG00000104643	ENSG00000136573
Uniprot IDs		Q96QG7	P51451 Q05D26
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Protein Tyrosine Kinase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Neuregulin Receptor Activity Phosphatidylinositol Dephosphorylation Protein Kinase Activity Phospholipid Dephosphorylation Phosphatidylinositol Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Kinase Activity Developmental Maturation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Establishment Of Planar Polarity Protein Tyrosine Phosphatase Activity Phosphatidylinositol Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Dephosphorylation Neuron Maturation Glycerolipid Metabolic Process Protein Binding Establishment Of Planar Polarity Involved In Nephron Morphogenesis Lipid Modification PAS Complex Phospholipid Metabolic Process Cell Maturation	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Phosphotyrosine Residue Binding B Cell Activation Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cellular Developmental Process Developmental Process Mononuclear Cell Differentiation Lymphocyte Differentiation Regulation Of Intracellular Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphatase Binding Regulation Of Developmental Process Leukocyte Differentiation Animal Organ Development Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Male Gonad Development Regulation Of Programmed Cell Death Cell Differentiation Regulation Of Cell Communication Regulation Of Signaling Cell Activation Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Signal Transduction Gonad Development ErbB-3 Class Receptor Binding Intracellular Signal Transduction Ovarian Follicle Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Immune System Process ERBB2 Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Basal Plasma Membrane Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Population Proliferation Reproductive Structure Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development