MTMR9 and MTMR8

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		MTMR9	MTMR8
Description		myotubularin related protein 9	myotubularin related protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nuclear Envelope Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity
	Biological Process	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation	Lipid Metabolic Process Negative Regulation Of Autophagy Regulation Of Macroautophagy Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Essential hypertension (time to event) ( 32589924) Extraversion ( 27918536) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: AATK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655	3 interacting genes: AATK ERBB3 MTMR9
Entrez ID		66036	55613
HPRD ID		09377	06664
Ensembl ID		ENSG00000104643	ENSG00000102043
Uniprot IDs		Q96QG7	Q96EF0
PDB IDs			4Y7I
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Protein Tyrosine Kinase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Neuregulin Receptor Activity Phosphatidylinositol Dephosphorylation Protein Kinase Activity Phospholipid Dephosphorylation Phosphatidylinositol Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Kinase Activity Developmental Maturation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Establishment Of Planar Polarity Protein Tyrosine Phosphatase Activity Phosphatidylinositol Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Dephosphorylation Neuron Maturation Glycerolipid Metabolic Process Protein Binding Establishment Of Planar Polarity Involved In Nephron Morphogenesis Lipid Modification PAS Complex Phospholipid Metabolic Process Cell Maturation	Neuron Apoptotic Process Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Positive Regulation Of Dephosphorylation Schwann Cell Differentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Phosphatase Activity Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Kinase Activity Endocardial Cushion Development Protein Tyrosine Kinase Activator Activity Positive Regulation Of Striated Muscle Tissue Development Kinase Activity Schwann Cell Development ERBB2 Signaling Pathway Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Dephosphorylation Phosphatidylinositol Dephosphorylation Peripheral Nervous System Development Perinuclear Region Of Cytoplasm Enzyme Regulator Activity Cranial Nerve Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Phospholipid Dephosphorylation Regulation Of Phospholipid Metabolic Process Regulation Of Striated Muscle Tissue Development Growth Factor Binding Apoptotic Process Regulation Of Muscle Organ Development Cell Death Nerve Development Programmed Cell Death Positive Regulation Of Calcium-mediated Signaling Mesenchyme Development Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Lateral Plasma Membrane
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