MTMR9 and MTMR6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, genetic interference)
HPRD (in vitro, in vivo)

		MTMR9	MTMR6
Description		myotubularin related protein 9	myotubularin related protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity
	Biological Process	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Essential hypertension (time to event) ( 32589924) Extraversion ( 27918536) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 31628463) Triglyceride levels ( 32203549)
Interacting Genes		26 interacting genes: AATK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655	14 interacting genes: AATK ALKBH4 AMOTL2 ERBB3 ERBB4 LMTK2 MTMR9 MTNR1B MTUS2 NMI PTK7 RARG ROR2 TRIM27
Entrez ID		66036	9107
HPRD ID		09377	11946
Ensembl ID		ENSG00000104643	ENSG00000139505
Uniprot IDs		Q96QG7	A0A9L9PXJ0 Q9Y217
PDB IDs			2YF0
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Protein Tyrosine Kinase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Neuregulin Receptor Activity Phosphatidylinositol Dephosphorylation Protein Kinase Activity Phospholipid Dephosphorylation Phosphatidylinositol Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Kinase Activity Developmental Maturation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Establishment Of Planar Polarity Protein Tyrosine Phosphatase Activity Phosphatidylinositol Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Dephosphorylation Neuron Maturation Glycerolipid Metabolic Process Protein Binding Establishment Of Planar Polarity Involved In Nephron Morphogenesis Lipid Modification PAS Complex Phospholipid Metabolic Process Cell Maturation	Neuregulin Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Wnt Signaling Pathway Kinase Activity ERBB2 Signaling Pathway Establishment Of Planar Polarity Regulation Of Type I Interferon Production Transferase Activity ATP Binding Receptor Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Protein Sumoylation Negative Regulation Of Type I Interferon Production DNA N6-methyladenine Demethylase Activity Positive Regulation Of Cardiac Muscle Tissue Development Heart Development ERBB3:ERBB2 Complex Basal Plasma Membrane Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Coreceptor Activity Cellular Response To Retinoic Acid Protein Polyubiquitination Regulation Of Interferon-beta Production Myosin VI Binding Cleavage Furrow Ingression Wound Healing ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication ErbB-3 Class Receptor Binding Neuron Apoptotic Process Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Developmental Growth Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Melatonin Receptor Activity Regulation Of Neuronal Action Potential Camera-type Eye Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
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