SLC12A1 and TCF12

Data Source: HiPPIP (Novel)

		SLC12A1	TCF12
Name		solute carrier family 12 member 1	transcription factor 12
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Sodium:potassium:chloride Symporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Transmembrane Transporter Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell Volume Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide	None
Diseases		Bartter syndrome	None
GWAS		Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Metabolite levels (Pyroglutamine) ( 23934736 ) Systemic lupus erythematosus ( 26606652 )	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Alcohol consumption (drinks per week) ( 30643258 ) Apolipoprotein B levels ( 32203549 ) Body mass index ( 28892062 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Male-pattern baldness ( 28196072 ) Mean platelet volume ( 27863252 32888494 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30297969 )
Novel Interactors		1 novel interactors: TCF12	10 novel interactors: ACTB ADAM10 BCL2L10 MAPK6 RSL24D1 SCG3 SLC12A1 SLC24A1 SPTBN5 YKT6
Interacting Genes		3 interacting genes: OXSR1 STK39 USP40	68 interacting genes: AIRIM ARL16 ARMC8 ASCL4 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP ZNF688
Entrez ID		6557	6938
HPRD ID		02908	02725
Ensembl ID		ENSG00000074803	ENSG00000140262
Uniprot IDs		A0A8I5KSK6 B4DPF4 Q13621 Q8IUN5	F5GY10 Q99081
PDB IDs		Not available	2KNH 4JOL
GO Terms Enriched among Interactors		Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Ion Channel Regulator Activity Cellular Hypotonic Response Potassium Channel Inhibitor Activity Hypotonic Response Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Renal Sodium Ion Absorption Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Negative Regulation Of Cation Transmembrane Transport Response To Osmotic Stress Negative Regulation Of Monoatomic Ion Transmembrane Transport Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Transmembrane Transport Renal System Process Protein Autophosphorylation Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Regulation Of Leukocyte Migration Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Cellular Component Size	Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process