SLC12A1 and OXSR1

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)
HPRD (two hybrid)

		SLC12A1	OXSR1
Description		solute carrier family 12 member 1	oxidative stress responsive kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Sodium:potassium:chloride Symporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Transmembrane Transporter Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Ion Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell Volume Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Protein Phosphorylation Cell Volume Homeostasis Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of T Cell Chemotaxis Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide	Fostamatinib
Diseases		Bartter syndrome
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)	Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: OXSR1 STK39 USP40	14 interacting genes: AKT1 APP BMPR1B OGT PAK1 RELL1 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1 WNK1 WNK2 WNK4
Entrez ID		6557	9943
HPRD ID		02908	06809
Ensembl ID		ENSG00000074803	ENSG00000172939
Uniprot IDs		A0A8I5KSK6 B4DPF4 Q13621 Q8IUN5	O95747
PDB IDs			2V3S 2VWI 3DAK 7OKW
Enriched GO Terms of Interacting Partners?		Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Ion Channel Regulator Activity Cellular Hypotonic Response Potassium Channel Inhibitor Activity Hypotonic Response Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Renal Sodium Ion Absorption Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Negative Regulation Of Cation Transmembrane Transport Response To Osmotic Stress Negative Regulation Of Monoatomic Ion Transmembrane Transport Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Transmembrane Transport Renal System Process Protein Autophosphorylation Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Regulation Of Leukocyte Migration Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Cellular Component Size	Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chemical Homeostasis Protein Serine/threonine Kinase Activity Cell Volume Homeostasis Potassium Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Intracellular Chloride Ion Homeostasis Monoatomic Ion Homeostasis Protein Kinase Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Regulation Of Sodium Ion Transport Transferase Activity Homeostatic Process Kinase Activity Regulation Of Cell Size Cellular Homeostasis Response To Stress Inorganic Ion Homeostasis Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Protein-containing Complex Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Intracellular Chemical Homeostasis Protein Metabolic Process Sodium Ion Transmembrane Transport Regulation Of Developmental Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Inorganic Anion Transport Monoatomic Anion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Protein Localization Potassium Ion Import Across Plasma Membrane Positive Regulation Of Developmental Process Metal Ion Transport Regulation Of Developmental Process Regulation Of Protein Localization To Cell Periphery Protein Phosphorylation Inorganic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Spontaneous Synaptic Transmission SMAD Binding
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