SLC12A1 and STK39

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SLC12A1	STK39
Description		solute carrier family 12 member 1	serine/threonine kinase 39
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Body
	Molecular Function	Sodium:potassium:chloride Symporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Transmembrane Transporter Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Transmembrane Transporter Binding Ion Channel Regulator Activity Protein Serine Kinase Activity Transporter Activator Activity Transporter Inhibitor Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell Volume Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Response To Dietary Excess Protein Phosphorylation Cell Volume Homeostasis Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Chloride Ion Homeostasis Negative Regulation Of Transmembrane Transport Intracellular Signal Transduction Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Macrophage Activation Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Monoatomic Ion Homeostasis Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Aldosterone Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide	Fostamatinib
Diseases		Bartter syndrome
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)	Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Daytime nap ( 33568662) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		3 interacting genes: OXSR1 STK39 USP40	15 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TMEM132D TSC22D2 WNK4
Entrez ID		6557	27347
HPRD ID		02908	09627
Ensembl ID		ENSG00000074803	ENSG00000198648
Uniprot IDs		A0A8I5KSK6 B4DPF4 Q13621 Q8IUN5	A0A8V8TKT5 Q9UEW8
PDB IDs			7O86
Enriched GO Terms of Interacting Partners?		Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Ion Channel Regulator Activity Cellular Hypotonic Response Potassium Channel Inhibitor Activity Hypotonic Response Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Renal Sodium Ion Absorption Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Negative Regulation Of Cation Transmembrane Transport Response To Osmotic Stress Negative Regulation Of Monoatomic Ion Transmembrane Transport Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Transmembrane Transport Renal System Process Protein Autophosphorylation Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Regulation Of Leukocyte Migration Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Cellular Component Size	Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Cell Volume Homeostasis Potassium Ion Homeostasis Inorganic Anion Transport Monoatomic Anion Transport Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Intracellular Chloride Ion Homeostasis Response To Osmotic Stress Regulation Of Cell Size Regulation Of Cellular Component Size Inorganic Cation Import Across Plasma Membrane Chloride Transmembrane Transport Symporter Activity Response To Dietary Excess Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Response To Muscle Stretch Protein Serine Kinase Activity Sodium Ion Transmembrane Transport Import Across Plasma Membrane Protein Serine/threonine Kinase Activity Maintenance Of Blood-brain Barrier Aggresome Inorganic Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transporter Activity Sodium Ion Transport Homeostatic Process Multicellular Organismal-level Homeostasis Renal Absorption Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of T-helper 2 Cell Activation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Cell Volume Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Aldosterone Secretion Protein Kinase Activity Regulation Of Cell-cell Adhesion MAPK Cascade Basolateral Plasma Membrane
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