SLC12A1 and STK39

Number of citations of the paper that reports this interaction (PMID 12386165)
76

Data Source:
HPRD (two hybrid)

		SLC12A1	STK39
Gene Name		solute carrier family 12 (sodium/potassium/chloride transporter), member 1	serine threonine kinase 39
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Sodium:potassium:chloride Symporter Activity	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Kidney Development Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Excretion Ion Transmembrane Transport Chemical Homeostasis Transmembrane Transport Chloride Transmembrane Transport	Protein Phosphorylation Response To Stress Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Potassium Ion Transport Regulation Of Inflammatory Response Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium Chloride Hydroflumethiazide Bumetanide Ethacrynic acid Trichlormethiazide Quinethazone Piretanide
Diseases
GWAS			Blood pressure ( 19114657) Parkinson's disease ( 21292315)
Protein-Protein Interactions		2 interactors: OXSR1 STK39	13 interactors: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 WNK4
Entrez ID		6557	27347
HPRD ID		02908	09627
Ensembl ID		ENSG00000074803	ENSG00000198648
Uniprot IDs		B4DPF4 E9PDW4 Q13621 Q8IUN5	Q9UEW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Positive Regulation Of Potassium Ion Transport Protein Phosphorylation Cellular Response To Stress Phosphorylation Intracellular Signal Transduction Peptidyl-serine Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Ion Transport Cellular Protein Modification Process Response To Stress Regulation Of Inflammatory Response Cellular Protein Metabolic Process Response To Oxidative Stress	Chloride Transport System Development Negative Regulation Of Axonogenesis Multicellular Organismal Development Inorganic Anion Transport Anatomical Structure Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Developmental Process Chloride Transmembrane Transport Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Response To Stress Regulation Of Axonogenesis Positive Regulation Of Interleukin-4 Production Negative Regulation Of Neuron Differentiation Regulation Of Interleukin-4 Production Response To External Stimulus Potassium Ion Transport Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Organ Development Anion Transport Monovalent Inorganic Cation Transport Sodium Ion Transport Tissue Regeneration Developmental Growth Negative Regulation Of Neurogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Regulation Of Cellular Component Size Negative Regulation Of Cell Development Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury P38MAPK Cascade Anatomical Structure Morphogenesis Metal Ion Transport Regulation Of Cell Growth Execution Phase Of Apoptosis Response To Stimulus Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Response To Osmotic Stress Neurogenesis Negative Regulation Of Developmental Growth Anion Transmembrane Transport Tissue Development Positive Regulation Of T-helper 2 Cell Activation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Tagcloud ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold	atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plcd3 plekha7 sh2b3 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Difference) ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold	atp2b1 atxn2 bdkrb2 cacnb2 csk cyp171a cyp17a1 cyp1a2 eh gwas hfe jan meant mthfr nppa nppb nt5c2 overlapped pharmacogenomics plcd3 plekha7 sh2b3 tbx3 tbx5 ulk3 ulk4 umod wnk4 znf652
Tagcloud (Intersection) ?