SLC12A1

Description		solute carrier family 12 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Sodium:potassium:chloride Symporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Cell Volume Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide
Diseases		Bartter syndrome
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)
Novel Interacting Genes		1 novel interacting genes: TCF12
Interacting Genes		3 interacting genes: OXSR1 STK39 USP40
Entrez ID		6557
HPRD ID		02908
Ensembl ID		ENSG00000074803
Uniprot IDs		A0A8I5KSK6 B4DPF4 Q13621 Q8IUN5
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Ion Channel Regulator Activity Cellular Hypotonic Response Potassium Channel Inhibitor Activity Hypotonic Response Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Renal Sodium Ion Absorption Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Negative Regulation Of Cation Transmembrane Transport Response To Osmotic Stress Negative Regulation Of Monoatomic Ion Transmembrane Transport Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Transmembrane Transport Renal System Process Protein Autophosphorylation Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Regulation Of Leukocyte Migration Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Pancreatic Juice Secretion Regulation Of Cellular Component Size
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