SLC12A1

Gene Name		solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Sodium:potassium:chloride Symporter Activity
	Biological Process	Kidney Development Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Excretion Ion Transmembrane Transport Chemical Homeostasis Transmembrane Transport Chloride Transmembrane Transport
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium Chloride Hydroflumethiazide Bumetanide Ethacrynic acid Trichlormethiazide Quinethazone Piretanide
Diseases
GWAS
Protein-protein Interactions		2 interactors: OXSR1 STK39
Entrez ID		6557
HPRD ID		02908
Ensembl ID		ENSG00000074803
Uniprot IDs		B4DPF4 E9PDW4 Q13621 Q8IUN5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Positive Regulation Of Potassium Ion Transport Protein Phosphorylation Cellular Response To Stress Phosphorylation Intracellular Signal Transduction Peptidyl-serine Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Ion Transport Cellular Protein Modification Process Response To Stress Regulation Of Inflammatory Response Cellular Protein Metabolic Process Response To Oxidative Stress
Tagcloud ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold