SFTPA1 and PRDX6

Number of citations of the paper that reports this interaction (PubMedID 16330552)
0

Data Source:
BioGRID (pull down)

		SFTPA1	PRDX6
Description		surfactant protein A1	peroxiredoxin 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Lipid Transporter Activity Protein Binding Carbohydrate Binding	Catalytic Activity Peroxidase Activity Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity
	Biological Process	Lipid Transport Respiratory Gaseous Exchange By Respiratory System Opsonization	Lipid Metabolic Process Response To Oxidative Stress Lipid Catabolic Process Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Detoxification of Reactive Oxygen Species Neutrophil degranulation
Drugs		2-(N-morpholino)ethanesulfonic acid	2-(N-morpholino)ethanesulfonic acid Copper
Diseases
GWAS			Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		2 interacting genes: DMBT1 PRDX6	22 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SEPHS2 SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE
Entrez ID		653509	9588
HPRD ID		19256	03817
Ensembl ID		ENSG00000122852	ENSG00000117592
Uniprot IDs		B4DNP6 K4N2H0 Q8IWL2	P30041 V9HWC7
PDB IDs			1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?		Zymogen Binding Reactive Oxygen Species Metabolic Process Receptor-mediated Endocytosis Defense Response To Bacterium Lipoteichoic Acid Binding Induction Of Bacterial Agglutination Extracellular Space 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Heparan Sulfate Binding Response To Bacterium Calcium-independent Phospholipase A2 Activity Extracellular Region Endocytosis Lysosome Scavenger Receptor Activity Zymogen Granule Membrane Defense Response To Other Organism Import Into Cell Innate Immune Response Defense Response To Symbiont Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Macrophage Migration Surfactant Homeostasis Negative Regulation Of Interleukin-2 Production Macrophage Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Response To Stress Lipopolysaccharide Binding Pattern Recognition Receptor Activity Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis Lung Alveolus Development Multivesicular Body	Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nuclear Receptor Activity Positive Regulation Of Telomere Maintenance Death Effector Domain Binding Response To Stress Intracellular Receptor Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Response To Estradiol Ripoptosome Positive Regulation Of Metabolic Process Response To External Biotic Stimulus CD95 Death-inducing Signaling Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Shelterin Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Telomere Cap Complex Nucleus G-rich Strand Telomeric DNA Binding Connective Tissue Development Telomere Capping Apoptotic Process Response To Vitamin Response To Vitamin A Programmed Cell Death Cell Death Protein Tag Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Interleukin-1 Beta Production Telomere Maintenance Positive Regulation Of Execution Phase Of Apoptosis Glutathione Peroxidase Activity Face Development Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Regulation Of Interleukin-1 Production Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Response To Ethanol Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding
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