SFTPA1 and DMBT1

Number of citations of the paper that reports this interaction (PubMedID 10101009)
0

Data Source:
BioGRID (pull down, pull down)

		SFTPA1	DMBT1
Description		surfactant protein A1	deleted in malignant brain tumors 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle	Extracellular Region Extracellular Space Cytoplasm Membrane Phagocytic Vesicle Membrane Extracellular Matrix Zymogen Granule Membrane Extracellular Exosome
	Molecular Function	Lipid Transporter Activity Protein Binding Carbohydrate Binding	Lipopolysaccharide Binding DNA Binding Scavenger Receptor Activity Protein Binding Zymogen Binding Pattern Recognition Receptor Activity Calcium-dependent Protein Binding Lipoteichoic Acid Binding Heparan Sulfate Binding
	Biological Process	Lipid Transport Respiratory Gaseous Exchange By Respiratory System Opsonization	Receptor-mediated Endocytosis Defense Response Protein Transport Vesicle-mediated Transport Cell Differentiation Epithelial Cell Differentiation Induction Of Bacterial Agglutination Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Surfactant metabolism
Drugs		2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Iris heterochromicity ( 30895295)
Interacting Genes		2 interacting genes: DMBT1 PRDX6	3 interacting genes: SFTPA1 SFTPD UBC
Entrez ID		653509	1755
HPRD ID		19256	03575
Ensembl ID		ENSG00000122852	ENSG00000187908
Uniprot IDs		B4DNP6 K4N2H0 Q8IWL2	A0A590UJ76 Q9UGM3
PDB IDs			6SA4 6SA5 6SAN 8J8D 8J8T 8WZS
Enriched GO Terms of Interacting Partners?		Zymogen Binding Reactive Oxygen Species Metabolic Process Receptor-mediated Endocytosis Defense Response To Bacterium Lipoteichoic Acid Binding Induction Of Bacterial Agglutination Extracellular Space 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Heparan Sulfate Binding Response To Bacterium Calcium-independent Phospholipase A2 Activity Extracellular Region Endocytosis Lysosome Scavenger Receptor Activity Zymogen Granule Membrane Defense Response To Other Organism Import Into Cell Innate Immune Response Defense Response To Symbiont Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Macrophage Migration Surfactant Homeostasis Negative Regulation Of Interleukin-2 Production Macrophage Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Response To Stress Lipopolysaccharide Binding Pattern Recognition Receptor Activity Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis Lung Alveolus Development Multivesicular Body	Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Extracellular Space Multivesicular Body Collagen Trimer Methanethiol Oxidase Activity
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