SFTPA1

Description		surfactant protein A1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle
	Molecular Function	Lipid Transporter Activity Protein Binding Carbohydrate Binding
	Biological Process	Lipid Transport Respiratory Gaseous Exchange By Respiratory System Opsonization
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: SFTPD
Interacting Genes		2 interacting genes: DMBT1 PRDX6
Entrez ID		653509
HPRD ID		19256
Ensembl ID		ENSG00000122852
Uniprot IDs		B4DNP6 K4N2H0 Q8IWL2
PDB IDs
Enriched GO Terms of Interacting Partners?		Zymogen Binding Reactive Oxygen Species Metabolic Process Receptor-mediated Endocytosis Defense Response To Bacterium Lipoteichoic Acid Binding Induction Of Bacterial Agglutination Extracellular Space 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Heparan Sulfate Binding Response To Bacterium Calcium-independent Phospholipase A2 Activity Extracellular Region Endocytosis Lysosome Scavenger Receptor Activity Zymogen Granule Membrane Defense Response To Other Organism Import Into Cell Innate Immune Response Defense Response To Symbiont Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Macrophage Migration Surfactant Homeostasis Negative Regulation Of Interleukin-2 Production Macrophage Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Response To Stress Lipopolysaccharide Binding Pattern Recognition Receptor Activity Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis Lung Alveolus Development Multivesicular Body
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