ZBTB8A and HIC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB8A	HIC2
Description		zinc finger and BTB domain containing 8A	HIC ZBTB transcriptional repressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS			Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Interacting Genes		76 interacting genes: ACOT12 AEN AP1M1 AP2M1 ARMC7 ARMCX1 BAZ2B BLK BYSL CBX8 CCDC33 CDC37 CDKL3 CEP70 CSNK1D CWF19L2 DDX6 DVL2 DVL3 EHHADH EIF1AD EP300 FAM161A FAM90A1 FXR2 GPATCH2L HIC2 JRK KAT5 KAT7 KIF5B KIF9 KIFC3 LGALS14 LMO3 LNX1 MCM10 MFAP1 MRPL11 MYO15B NTAQ1 PAXIP1 PIAS2 PRKAA2 PRPF3 PRR34 PSMC1 RAD23A RPL9 SDCBP SYT6 TCEA2 TNIP3 TRIM41 UBE2I YES1 ZBTB17 ZBTB24 ZBTB48 ZBTB49 ZCCHC10 ZGPAT ZMAT2 ZNF138 ZNF250 ZNF276 ZNF329 ZNF35 ZNF408 ZNF417 ZNF438 ZNF497 ZNF572 ZNF587 ZNF648 ZNF837	9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A
Entrez ID		653121	23119
HPRD ID		18902	07412
Ensembl ID		ENSG00000160062	ENSG00000169635
Uniprot IDs		D3DPQ1 Q96BR9	Q96JB3
PDB IDs			7TXC
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Regulation Of Macromolecule Metabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Nucleoplasm Histone Acetyltransferase Activity Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Acetylation Organelle Disassembly Regulation Of Metabolic Process Positive Regulation Of Neuron Projection Arborization Frizzled Binding Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Histone H4K16 Acetyltransferase Activity Identical Protein Binding Internal Protein Amino Acid Acetylation Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Kinesin Complex Signal Transduction By P53 Class Mediator	Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Positive Regulation Of JNK Cascade Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Negative Regulation Of DNA-templated Transcription Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling P-TEFb Complex Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Phenotypic Switching Histone H3K56 Methyltransferase Activity Peptidyl-lysine Dimethylation Histone H3K27 Methyltransferase Activity
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