HIC2 and PDK2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HIC2	PDK2
Gene Name		hypermethylated in cancer 2	pyruvate dehydrogenase kinase, isozyme 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	DNA Binding Protein C-terminus Binding Metal Ion Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Cellular Metabolic Process Small Molecule Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Protein-Protein Interactions		4 interactors: APP CCNT1 HIC1 PDK2	10 interactors: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		23119	5164
HPRD ID		07412	03955
Ensembl ID		ENSG00000169635	ENSG00000005882
Uniprot IDs		Q96JB3	B4DLP2 Q15119
PDB IDs			2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Cell Death Death Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Axon Choice Point Recognition Apoptotic Signaling Pathway Neuron Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Phosphorylation Response To Oxidative Stress Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Copper Ion Homeostasis Ion Homeostasis Signaling Cell Communication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Kinase Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Cellular Response To Nutrient Regulation Of Kinase Activity Phosphate-containing Compound Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Gluconeogenesis Chemical Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Hexose Metabolic Process Monocarboxylic Acid Metabolic Process Monosaccharide Metabolic Process Regulation Of Phosphorus Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Plasma Membrane Organic Acid Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Ion Transport Small Molecule Metabolic Process Regulation Of Establishment Of Protein Localization To Plasma Membrane Tricarboxylic Acid Cycle Positive Regulation Of Transport Citrate Metabolic Process Response To Hypoxia Regulation Of T Cell Activation Regulation Of Protein Localization To Plasma Membrane Energy Derivation By Oxidation Of Organic Compounds Regulation Of Metabolic Process Endocrine Pancreas Development Tricarboxylic Acid Metabolic Process Positive Regulation Of Transporter Activity Aerobic Respiration Regulation Of Cell-cell Adhesion Neural Plate Formation Glycogen Cell Differentiation Involved In Embryonic Placenta Development T Cell Costimulation Apoptotic Process Regulation Of Lymphocyte Activation Programmed Cell Death Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Cell Death Death Positive Regulation Of Calcium Ion Transport Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation
Tagcloud ?			addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft
Tagcloud (Difference) ?			addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft
Tagcloud (Intersection) ?