HIC2 and HIC1

Number of citations of the paper that reports this interaction (PubMedID 11554746)
0

Data Source:
BioGRID (two hybrid, imaging technique)

		HIC2	HIC1
Description		HIC ZBTB transcriptional repressor 2	HIC ZBTB transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways			SUMOylation of transcription factors
Drugs
Diseases
GWAS		Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465)
Interacting Genes		9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A	12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I
Entrez ID		23119	3090
HPRD ID		07412	04826
Ensembl ID		ENSG00000169635	ENSG00000177374
Uniprot IDs		Q96JB3	A0PJI1 Q14526
PDB IDs		7TXC
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Positive Regulation Of JNK Cascade Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Negative Regulation Of DNA-templated Transcription Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling P-TEFb Complex Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Phenotypic Switching Histone H3K56 Methyltransferase Activity Peptidyl-lysine Dimethylation Histone H3K27 Methyltransferase Activity	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transcription Corepressor Activity White Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway HLH Domain Binding Transcription Coregulator Binding Nuclear Receptor Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Modification Process Transcription Coactivator Activity Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Histone Deacetylase Activity Viral Genome Replication SUMO Transferase Activity Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation
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