HIC2 and CCNT1

Number of citations of the paper that reports this interaction (PMID 12944466)
15

Data Source:
HPRD (two hybrid, in vivo)

		HIC2	CCNT1
Gene Name		hypermethylated in cancer 2	cyclin T1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane	Nucleus Nucleoplasm Nucleolus Positive Transcription Elongation Factor Complex B
	Molecular Function	DNA Binding Protein C-terminus Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding SnRNA Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division
Pathways			Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Protein-Protein Interactions		4 interactors: APP CCNT1 HIC1 PDK2	26 interactors: AFF4 AHR BRD4 CDK9 CTD ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MBP MDFIC MYC NCOA2 NUFIP1 PML POLR2A PURA RN7SK SKP2 SUPT5H
Entrez ID		23119	904
HPRD ID		07412	03938
Ensembl ID		ENSG00000169635	ENSG00000129315
Uniprot IDs		Q96JB3	A8K4M5 A9XU13 O60563
PDB IDs			2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Surface Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Cell Death Death Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Axon Choice Point Recognition Apoptotic Signaling Pathway Neuron Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Phosphorylation Response To Oxidative Stress Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Copper Ion Homeostasis Ion Homeostasis Signaling Cell Communication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Kinase Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation Neuron Recognition Cellular Response To Nutrient Regulation Of Kinase Activity Phosphate-containing Compound Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Gluconeogenesis Chemical Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Viral Transcription Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Viral Transcription Regulation Of Viral Process Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cell Cycle Transcription Elongation From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity 7-methylguanosine MRNA Capping Positive Regulation Of Metabolic Process
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