CLDN3 and TJP1

Number of citations of the paper that reports this interaction (PMID 10601346)
178

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CLDN3	TJP1
Gene Name		claudin 3	tight junction protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Tight Junction Integral Component Of Membrane Lateral Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Response To Hypoxia Epithelial Cell Morphogenesis Signal Transduction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		7 interactors: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		1365	7082
HPRD ID		04219	03002
Ensembl ID		ENSG00000165215	ENSG00000104067
Uniprot IDs		O15551 Q75L79	G3V1L9 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Chemical Homeostasis Homeostatic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Multicellular Organismal Water Homeostasis Cellular Response To Glucose Stimulus Water Homeostasis Nuclear Envelope Organization Cell Adhesion Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Cell-cell Signaling Involved In Cell-cell Junction Organization Positive Regulation Of Dense Core Granule Biogenesis Renal System Process Regulation Of Glucose Transport Cellular Chemical Homeostasis Multicellular Organismal Development Ion Homeostasis Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Mitotic Cell Cycle Cell-cell Junction Assembly Nucleus Organization Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Response To Glucose Regulation Of Protein Binding Cell Maturation Cellular Homeostasis Distal Tubule Morphogenesis Collateral Sprouting In Absence Of Injury Developmental Process Renal Sodium Ion Absorption Response To Magnetism Response To Carbohydrate Platelet Activation Collateral Sprouting Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Axon Midline Choice Point Recognition Cell Junction Assembly Membrane Organization Glucose Homeostasis Pathogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Cycle Process Peptidyl-serine Autophosphorylation	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?		anat asmt characterise circumventricular col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo slc22a3 specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?		anat asmt characterise circumventricular col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo slc22a3 specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?