SLC7A7

Description		solute carrier family 7 member 7
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding Basic Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Regulation Of Arginine Metabolic Process Amino Acid Transmembrane Transport Amino Acid Transport L-leucine Transport Transmembrane Transport L-arginine Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Drugs		Fluciclovine (18F)
Diseases		Lysinuric protein intolerance (LPI)
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Intraocular pressure ( 30591961) Iris color (b* coordinate) ( 30895295) Psychological resilience (outcome-based) in high deployment stress exposure ( 31081985) Resting-state electroencephalogram vigilance ( 29703947) Type 2 diabetes ( 30297969)
Interacting Genes		2 interacting genes: NEDD4L SLC3A2
Entrez ID		9056
HPRD ID		04667
Ensembl ID		ENSG00000155465
Uniprot IDs		A0A0S2Z502 Q9UM01
PDB IDs		8XXI 8XYJ 8YLP
Enriched GO Terms of Interacting Partners?		Import Across Plasma Membrane Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Apical Plasma Membrane Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis L-alanine Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis L-alanine Transport Aromatic Amino Acid Transport Metal Ion Transport Branched-chain Amino Acid Transport L-leucine Transport Proline Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transmembrane Transport Import Into Cell Thyroid Hormone Transport Negative Regulation Of Protein Localization To Cell Surface Regulation Of Potassium Ion Export Across Plasma Membrane Alanine Transport Sulfur Amino Acid Transport Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Ventricular Cardiac Muscle Cell Action Potential Neutral L-amino Acid Transmembrane Transporter Activity Receptor Catabolic Process Basic Amino Acid Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Potassium Ion Transmembrane Transport Monoatomic Ion Transport Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transport Sodium Channel Regulator Activity Amino Acid Import Across Plasma Membrane
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