EBP and C2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EBP	C2
Description		EBP cholestenol delta-isomerase	complement C2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Nuclear Membrane	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Cell Surface Extracellular Exosome Symbiont Cell Surface
	Molecular Function	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Protein Binding Hydrolase Activity Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Identical Protein Binding Cholestenol Delta-isomerase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Hemopoiesis Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Ossification Involved In Bone Maturation	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Opsonization Response To Bacterium Killing Of Cells Of Another Organism Response To Lipopolysaccharide Innate Immune Response Protein Maturation Response To Thyroid Hormone Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs		Tamoxifen
Diseases			Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS			A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age at first sexual intercourse ( 34211149) Age-related macular degeneration ( 20385826 23455636 20385819 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Circulating myeloperoxidase levels (serum) ( 23620142) Clostridioides difficle infection ( 33841421) Coffee consumption ( 31046077) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Hepatocellular carcinoma ( 21105107) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		172 interacting genes: ABHD16A ANKRD46 APP AQP6 ARL13B ARL6IP6 ARLN ARV1 ATP13A1 BMP10 BNIP3 BTN2A2 C2 C2CD2L C5 C5orf46 CCDC167 CCL4L2 CD40 CD69 CD81 CDIPT CHODL CLDND2 CREB3 CREB3L1 CYB561 CYB5B CYP4F2 DEFB103A DEFB103B DEFB127 DNAJC30 EBPL EMC6 EMP1 ERG28 ERGIC3 ESRRG FA2H FAM209A FAXDC2 FCER1G FETUB FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 GIMAP1 GIMAP5 GJB2 GJB6 GLP1R GOSR2 GPR152 HMOX2 HSD17B13 IER3IP1 INSIG2 JAGN1 LDLRAD1 LEMD1 LPCAT2 LRP10 LRRC59 LTC4S MFSD6 MITF MMP14 MS4A13 MTNR1B NAT8 NDUFA3 NDUFB11 NEU1 NINJ1 NINJ2 NKG7 ODF4 ORMDL1 ORMDL2 ORMDL3 OTOP3 PLLP PLP2 PLPP6 PMP22 PNLIPRP1 PTPN9 PVR RNF152 RTP2 RUSF1 SACM1L SCAMP4 SEC22B SERP1 SERP2 SFXN5 SLC10A6 SLC35G1 SLC3A2 SLC41A2 SMAGP SMCO4 SMIM1 SMIM3 SNORC STX12 STX1B STX5 STX6 STX7 STX8 SYNGR1 SYNJ2BP SYS1 TBC1D20 THBD TIMM23 TLCD1 TLCD4 TMBIM6 TMEM100 TMEM11 TMEM120B TMEM140 TMEM147 TMEM14B TMEM14C TMEM167B TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM239 TMEM242 TMEM243 TMEM254 TMEM31 TMEM42 TMEM51 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMIE TRARG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBIAD1 UNC50 UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB VMA12 YIF1A YIPF1 YIPF4 YIPF6 ZDHHC24 ZFPL1	14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35H1 STOM
Entrez ID		10682	717
HPRD ID		02192	08939
Ensembl ID		ENSG00000147155	ENSG00000166278
Uniprot IDs		A0A024QYX0 Q15125	A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6
PDB IDs		6OHT 6OHU 8W0R 8W0S	2I6Q 2I6S 2ODP 2ODQ 3ERB 8ACF 8ACI
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Endomembrane System Cellular Localization Organelle Localization By Membrane Tethering SNARE Binding Vesicle Organization Membrane Docking Establishment Of Protein Localization Vesicle Docking Intracellular Transport Golgi Membrane Establishment Of Localization In Cell Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNARE Complex Assembly Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Secretion By Cell Chemical Homeostasis Negative Regulation Of Sphingolipid Biosynthetic Process Protein Transport Serine Palmitoyltransferase Complex Exocytosis Establishment Of Protein Localization To Membrane Endoplasmic Reticulum Unfolded Protein Response Sterol Biosynthetic Process Transport Vesicle Regulation Of Cellular Localization Alkenylglycerophosphocholine Hydrolase Activity Intracellular Chemical Homeostasis Host-mediated Activation Of Viral Genome Replication Golgi Apparatus Syntaxin Binding Nuclear Inner Membrane Host-mediated Perturbation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Intracellular Protein Localization Phagocytic Vesicle	Complement Activation, Lectin Pathway Complement Activation Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Opsonization Symbiont Cell Surface Humoral Immune Response Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Immune Effector Process Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Activation Of Membrane Attack Complex Positive Regulation Of Inflammatory Response To Antigenic Stimulus Extracellular Space Positive Regulation Of Immune System Process Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Innate Immune Response Receptor Ligand Activity Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Mononuclear Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Production Defense Response To Symbiont Defense Response To Other Organism Antigen Binding Positive Regulation Of Transport Cell Killing Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Lipid Storage Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Chemokine Activity Regulation Of Acute Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Leukocyte Migration Extracellular Exosome Regulation Of Immune Response Leukocyte Migration
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