GCN1

Name	GCN1 activator of EIF2AK4
Structure	No pdb structure
Novel Interactors	1 novel interactors: SLC2A1
Interactors	4 interactors: MYC RNF10 SUMO2 YWHAQ
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Membrane Cytosolic Ribosome
	Molecular Function	RNA Binding Translation Factor Activity, RNA Binding Protein Kinase Regulator Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ubiquitin-protein Transferase Regulator Activity Molecular Adaptor Activity Stalled Ribosome Sensor Activity
	Biological Process	Translational Elongation Regulation Of Translation Ubiquitin-dependent Protein Catabolic Process Cellular Response To Amino Acid Starvation Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination GCN2-mediated Signaling Protein-RNA Covalent Cross-linking Repair
Pathways	Response of EIF2AK4 (GCN2) to amino acid deficiency
GWAS	Appendicular lean mass ( 33097823 )
Entrez ID	10985
HPRD ID	16127
Ensembl ID	ENSG00000089154
Uniprot IDs	Q92616
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Glucose Transporter Complex Myc-Max Complex Regulation Of Acinar Cell Proliferation Fucose Transmembrane Transporter Activity Fucose Transmembrane Transport RNA Polymerase II Transcription Repressor Complex Negative Regulation Of DNA-templated Transcription Initiation NK T Cell Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Kidney Development Regulation Of Somatic Stem Cell Population Maintenance Response To Decreased Oxygen Levels Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation Response To Hypoxia Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Fibroblast Apoptotic Process NK T Cell Activation Negative Regulation Of Cell Development Cellular Response To Interferon-alpha Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Mechanical Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of B Cell Apoptotic Process B Cell Apoptotic Process Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II D-glucose Transmembrane Transporter Activity L-ascorbic Acid Metabolic Process Response To Thyroglobulin Triiodothyronine Dehydroascorbic Acid Transport Presynapse D-glucose Import Across Plasma Membrane Long-chain Fatty Acid Import Across Plasma Membrane Dehydroascorbic Acid Transmembrane Transporter Activity Long-chain Fatty Acid Import Into Cell Female Pronucleus Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Response To Oxygen Levels Female Germ Cell Nucleus Alpha-beta T Cell Proliferation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation