UPF3A and SMG1

Number of citations of the paper that reports this interaction (PubMedID 11544179)
46

Data Source:
HPRD (in vivo)

		UPF3A	SMG1
Description		UPF3A regulator of nonsense mediated mRNA decay	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Exon-exon Junction Complex Neuron Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Chromatoid Body
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Telomeric DNA Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay In Utero Embryonic Development Spermatogenesis Positive Regulation Of Translation MRNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus DNA Damage Response Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)	Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1	10 interacting genes: CDH5 PRKCI RNF10 SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		65110	23049
HPRD ID		09274	06123
Ensembl ID		ENSG00000169062	ENSG00000157106
Uniprot IDs		B3KUE7 Q9H1J1	Q96Q15
PDB IDs		2L08 7QG6	6L53 6L54 6SYT 6Z3R 7PW4 7PW5 7PW6 7PW7 7PW8 7PW9
Enriched GO Terms of Interacting Partners?		MRNA Export From Nucleus RNA Export From Nucleus Nuclear Export MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Translation Cellular Localization Post-transcriptional Regulation Of Gene Expression Intracellular Transport Transcription Export Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Establishment Of Localization In Cell Telomeric DNA Binding RNA Catabolic Process Response To Cytokine Response To Peptide Negative Regulation Of Gene Expression Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Peptidyl-serine Phosphorylation MRNA Metabolic Process Negative Regulation Of Protein Localization To Nucleus MRNA Binding Cellular Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Glial Cell Development Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Nucleobase-containing Compound Catabolic Process RNA Binding Acetylcholine Receptor Activator Activity Response To Interleukin-1 Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Macromolecule Catabolic Process MRNA Transport RNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleobase-containing Compound Transport MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Catabolic Process Nuclear Export Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Glial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of RNA Splicing Nuclear Transport Nucleocytoplasmic Transport Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Late Endosome To Lysosome Transport Nucleic Acid Metabolic Process Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Biosynthetic Process Cellular Localization Intracellular Monoatomic Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Regulation Of Gliogenesis Double-stranded DNA Helicase Activity Supraspliceosomal Complex VCB Complex Regulation Of Telomere Maintenance Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Golgi Vesicle Budding
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