UPF3A

Description		UPF3A regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Exon-exon Junction Complex Neuron Projection
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay In Utero Embryonic Development Spermatogenesis Positive Regulation Of Translation MRNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Novel Interacting Genes		1 novel interacting genes: ERBB2
Interacting Genes		9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1
Entrez ID		65110
HPRD ID		09274
Ensembl ID		ENSG00000169062
Uniprot IDs		B3KUE7 Q9H1J1
PDB IDs		2L08 7QG6
Enriched GO Terms of Interacting Partners?		MRNA Export From Nucleus RNA Export From Nucleus Nuclear Export MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Translation Cellular Localization Post-transcriptional Regulation Of Gene Expression Intracellular Transport Transcription Export Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Establishment Of Localization In Cell Telomeric DNA Binding RNA Catabolic Process Response To Cytokine Response To Peptide Negative Regulation Of Gene Expression Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Peptidyl-serine Phosphorylation MRNA Metabolic Process Negative Regulation Of Protein Localization To Nucleus MRNA Binding Cellular Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Glial Cell Development Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Nucleobase-containing Compound Catabolic Process RNA Binding Acetylcholine Receptor Activator Activity Response To Interleukin-1 Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation
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