UPF3A and ALYREF

Number of citations of the paper that reports this interaction (PMID 11546873)
80

Data Source:
HPRD (in vivo)

		UPF3A	ALYREF
Gene Name		UPF3 regulator of nonsense transcripts homolog A (yeast)	Aly/REF export factor
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Exon-exon Junction Complex Intracellular Membrane-bounded Organelle	Transcription Export Complex Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding RNA Binding Nucleocytoplasmic Transporter Activity Protein Binding	Nucleotide Binding Single-stranded DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Gene Expression Positive Regulation Of Translation MRNA Transport	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1	11 interactors: AKT1 DDX39B IL7R LEF1 MAGOH NXF1 RUNX2 THOC1 THOC6 THOC7 UPF3A
Entrez ID		65110	10189
HPRD ID		09274	09168
Ensembl ID		ENSG00000169062	ENSG00000183684
Uniprot IDs		B3KUE7 Q9H1J1	E9PB61 Q86V81
PDB IDs		2L08	3ULH
Enriched GO Terms of Interacting Partners?		Nuclear Export MRNA Export From Nucleus RNA Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport MRNA Transport RNA Transport RNA Localization Cytoplasmic Transport Intracellular Transport MRNA Metabolic Process Establishment Of Localization In Cell MRNA 3'-end Processing Cellular Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Translation Neuron Apoptotic Process Neuron Death DNA-templated Transcription, Termination Transport MRNA Processing Aromatic Compound Catabolic Process Response To Stress Gene Expression Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Type B Pancreatic Cell Development Synaptic Growth At Neuromuscular Junction Superior Temporal Gyrus Development Peptidyl-serine Phosphorylation RNA Processing Re-entry Into Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Negative Regulation Of Neuron Maturation Regulation Of Protein Binding Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Stress Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Interleukin-3 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Neuron Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Axon Choice Point Recognition	MRNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Viral MRNA Export From Host Cell Nucleus Nuclear Export Cytoplasmic Transport Intracellular Transport Of Virus Intracellular Transport Gene Expression MRNA Metabolic Process RNA Splicing Establishment Of Localization In Cell Regulation Of Cell Cycle Checkpoint MRNA Processing Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Gene Expression Viral Life Cycle Cellular Localization Viral Process RNA Processing Regulation Of DNA Damage Checkpoint RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Differentiation T Cell Differentiation Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Adaptive Immune Response B Cell Proliferation Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Activation Regulation Of Translation Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Aggregation T Cell Activation Ossification Lymphocyte Aggregation Leukocyte Aggregation
Tagcloud ?			ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet
Tagcloud (Difference) ?			ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet
Tagcloud (Intersection) ?