SLC4A3 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SLC4A3	UBASH3A
Description		solute carrier family 4 member 3	ubiquitin associated and SH3 domain containing A
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport PH Reduction Regulation Of Intracellular PH Transmembrane Transport Cardiac Conduction Cardiac Muscle Cell Action Potential Monoatomic Anion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Bicarbonate transporters
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 33713608) Immune response to measles-mumps-rubella vaccine ( 24811271) QT interval ( 29874175)	Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		6 interacting genes: ANK1 CA2 CA4 DRD2 PRKCE UBASH3A	105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1
Entrez ID		6508	53347
HPRD ID		00109	06904
Ensembl ID		ENSG00000114923	ENSG00000160185
Uniprot IDs		P48751	P57075
PDB IDs		8Y85 8Y86 8Y8K 8ZLE	2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission, GABAergic Secretion Positive Regulation Of Synaptic Transmission Carbonate Dehydratase Activity Positive Regulation Of Synaptic Transmission, GABAergic Cellular Response To Ethanol Response To Morphine Positive Regulation Of Cytokinesis Cell Periphery Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Monoatomic Ion Transport Cyanamide Hydratase Activity Modulation Of Chemical Synaptic Transmission Response To Alkaloid Positive Regulation Of Cell Division Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Response To Ethanol G Protein-coupled Receptor Complex Regulation Of Sodium Ion Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Cytokinesis Ethanol Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Hormone Secretion Lyase Activity Regulation Of Insulin Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process Arylesterase Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transport Regulation Of Chloride Transport Regulation Of Peptide Hormone Secretion Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity
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