SLC4A3 and ANK1

Number of citations of the paper that reports this interaction (PubMedID 8227202)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC4A3	ANK1
Description		solute carrier family 4 member 3	ankyrin 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band A Band Sarcolemma Neuron Projection Postsynaptic Membrane Cell Periphery Ankyrin-1 Complex
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Transmembrane Transporter Binding ATPase Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport PH Reduction Regulation Of Intracellular PH Transmembrane Transport Cardiac Conduction Cardiac Muscle Cell Action Potential Monoatomic Anion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Golgi Vesicle Transport Protein Localization To Plasma Membrane
Pathways		Bicarbonate transporters	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Drugs
Diseases			Hereditary spherocytosis (SPH)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 33713608) Immune response to measles-mumps-rubella vaccine ( 24811271) QT interval ( 29874175)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 20858683 34059833 31213470 24647736 28898252) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Insulin levels adjusted for BMI ( 24699409) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22456796 32499647 22885922 24509480 26818947 28869590 29358691 30054458 30297969 30718926)
Interacting Genes		6 interacting genes: ANK1 CA2 CA4 DRD2 PRKCE UBASH3A	28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN
Entrez ID		6508	286
HPRD ID		00109	01693
Ensembl ID		ENSG00000114923	ENSG00000029534
Uniprot IDs		P48751	B3KX39 P16157
PDB IDs		8Y85 8Y86 8Y8K 8ZLE	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2 7TW3 7TW5 7TW6 7UZQ 7UZU 7V0K 7V0M 7V0S 7V0X 8CS9 8CSL 8CSV 8CTE
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission, GABAergic Secretion Positive Regulation Of Synaptic Transmission Carbonate Dehydratase Activity Positive Regulation Of Synaptic Transmission, GABAergic Cellular Response To Ethanol Response To Morphine Positive Regulation Of Cytokinesis Cell Periphery Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Monoatomic Ion Transport Cyanamide Hydratase Activity Modulation Of Chemical Synaptic Transmission Response To Alkaloid Positive Regulation Of Cell Division Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Response To Ethanol G Protein-coupled Receptor Complex Regulation Of Sodium Ion Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Cytokinesis Ethanol Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Hormone Secretion Lyase Activity Regulation Of Insulin Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process Arylesterase Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transport Regulation Of Chloride Transport Regulation Of Peptide Hormone Secretion Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression	Ankyrin Binding Ankyrin-1 Complex Spectrin Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Z Disc Chemical Homeostasis Bicarbonate Transport Plasma Membrane M Band Cortical Cytoskeleton Structural Constituent Of Cytoskeleton Intracellular Chemical Homeostasis Actin Filament Binding Actin Filament Capping Homeostatic Process Negative Regulation Of Actin Filament Depolymerization Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Cellular Homeostasis Bicarbonate Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Membrane Intracellularly Gated Calcium Channel Activity Monoatomic Anion Transmembrane Transporter Activity Cortical Actin Cytoskeleton Inorganic Ion Transmembrane Transport Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Sarcoplasmic Reticulum Cell Cortex Negative Regulation Of Protein-containing Complex Disassembly Actin Cytoskeleton Organization Calmodulin Binding Transmembrane Transport Regulation Of Protein Depolymerization Intracellular Monoatomic Cation Homeostasis Actin Filament-based Process Antiporter Activity Secretory Granule Membrane Chloride Transmembrane Transport Focal Adhesion Cell-matrix Adhesion Chloride Transport Cytoplasmic Side Of Plasma Membrane Multicellular Organismal-level Iron Ion Homeostasis I Band Cell-cell Contact Zone
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