LDLRAD1 and VTI1B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LDLRAD1	VTI1B
Description		low density lipoprotein receptor class A domain containing 1	vesicle transport through interaction with t-SNAREs 1B
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Presynaptic Endosome Membrane
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Vesicle-mediated Transport	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Blood protein levels ( 30072576)
Interacting Genes		34 interacting genes: ADGRG7 ANKRD46 AQP1 BNIP2 BNIP3 BNIP3L CMTM7 CTXN3 CXCL9 EBP EMP3 GIMAP5 GPR25 IGFBP5 LAPTM5 MAL MALL MARCHF2 NINJ2 OLFM4 PLN PLPP6 PTTG1IP SEC22A SLC1A1 SLC41A2 TMEM147 TMEM190 TMEM218 TMEM79 UNC93B1 VAMP4 VTI1B ZFPL1	38 interacting genes: AQP6 ASGR2 BIK CD46 CD79A CFTR CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SAR1A SLC16A7 SLC18A1 SLC35H1 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59
Entrez ID		388633	10490
HPRD ID		17372	04440
Ensembl ID		ENSG00000203985	ENSG00000100568
Uniprot IDs		Q5T700	Q9UEU0
PDB IDs			2V8S
Enriched GO Terms of Interacting Partners?		Membrane Presynaptic Endosome Membrane Cellular Response To Mercury Ion Positive Regulation Of Membrane Permeability Lysosome Nuclear Envelope Response To Mercury Ion Mitochondrial Protein Catabolic Process Endoplasmic Reticulum Membrane Mitochondrial Outer Membrane Permeabilization Structural Constituent Of Myelin Sheath Response To Oxygen-glucose Deprivation Neurotransmitter Receptor Transport To Plasma Membrane Defense Response To Virus Negative Regulation Of Mitochondrial Membrane Potential Protein Binding Negative Regulation Of Membrane Potential Response To Decreased Oxygen Levels Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Regulation Of Membrane Permeability Neurotransmitter Receptor Transport Response To Oxygen Levels Endoplasmic Reticulum Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Establishment Of Protein Localization Golgi To Vacuole Transport Establishment Of Protein Localization To Membrane Lysosomal Membrane Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Defense Response Nitric Oxide Transmembrane Transporter Activity Negative Regulation Of Programmed Cell Death Metanephric Proximal Convoluted Tubule Segment 2 Development Nuclear Membrane Membrane Organization Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Hair Follicle Morphogenesis Negative Regulation Of Skeletal Muscle Hypertrophy Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Vesicle-mediated Transport D-aspartate Transmembrane Transporter Activity	Membrane Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering SNAP Receptor Activity Membrane Docking SNARE Complex SNARE Binding Vesicle-mediated Transport Endomembrane System Vesicle Fusion Organelle Membrane Fusion Organelle Localization Membrane Organization Organelle Fusion Membrane Fusion Vesicle Organization Cornified Envelope Assembly Intracellular Protein Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Membrane Assembly Positive Regulation Of Immune Effector Process SNARE Complex Assembly Endoplasmic Reticulum Membrane Regulation Of Insulin Secretion Regulation Of Protein Localization Regulation Of Peptide Hormone Secretion Regulation Of Cellular Localization Positive Regulation Of Exocytosis Exocytosis Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Nuclear Envelope Organization Protein Binding Water Transport Endoplasmic Reticulum Regulation Of Adaptive Immune Response Neurotransmitter Transport Schaffer Collateral - CA1 Synapse Establishment Of Localization In Cell Nitrate Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Protein Transport Presynaptic Active Zone Membrane High-affinity IgG Receptor Activity Inhibitory MHC Class Ib Receptor Activity
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