LDLRAD1 and MARCHF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LDLRAD1	MARCHF2
Description		low density lipoprotein receptor class A domain containing 1	membrane associated ring-CH-type finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Vesicle-mediated Transport	Endocytosis Protein Ubiquitination Suppression Of Viral Release By Host Antibacterial Innate Immune Response Antiviral Innate Immune Response Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		34 interacting genes: ADGRG7 ANKRD46 AQP1 BNIP2 BNIP3 BNIP3L CMTM7 CTXN3 CXCL9 EBP EMP3 GIMAP5 GPR25 IGFBP5 LAPTM5 MAL MALL MARCHF2 NINJ2 OLFM4 PLN PLPP6 PTTG1IP SEC22A SLC1A1 SLC41A2 TMEM147 TMEM190 TMEM218 TMEM79 UNC93B1 VAMP4 VTI1B ZFPL1	34 interacting genes: AQP6 CCL4 CD79A CDC34 CFTR CREB3L1 ERGIC3 F11R FAM209A FATE1 GJA8 GPX8 IKBKG KASH5 LDLRAD1 LGR4 MUC1 PEX12 PLPPR2 SCN3B SLC18A1 SSMEM1 STX6 SYNE4 TMEM106C TMEM179B TMEM52B TMEM86B TSPAN12 TSPO2 UBC UBE2D1 UBE2E1 UBE2H
Entrez ID		388633	51257
HPRD ID		17372	14361
Ensembl ID		ENSG00000203985	ENSG00000099785
Uniprot IDs		Q5T700	Q9P0N8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Presynaptic Endosome Membrane Cellular Response To Mercury Ion Positive Regulation Of Membrane Permeability Lysosome Nuclear Envelope Response To Mercury Ion Mitochondrial Protein Catabolic Process Endoplasmic Reticulum Membrane Mitochondrial Outer Membrane Permeabilization Structural Constituent Of Myelin Sheath Response To Oxygen-glucose Deprivation Neurotransmitter Receptor Transport To Plasma Membrane Defense Response To Virus Negative Regulation Of Mitochondrial Membrane Potential Protein Binding Negative Regulation Of Membrane Potential Response To Decreased Oxygen Levels Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Regulation Of Membrane Permeability Neurotransmitter Receptor Transport Response To Oxygen Levels Endoplasmic Reticulum Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Establishment Of Protein Localization Golgi To Vacuole Transport Establishment Of Protein Localization To Membrane Lysosomal Membrane Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Defense Response Nitric Oxide Transmembrane Transporter Activity Negative Regulation Of Programmed Cell Death Metanephric Proximal Convoluted Tubule Segment 2 Development Nuclear Membrane Membrane Organization Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Hair Follicle Morphogenesis Negative Regulation Of Skeletal Muscle Hypertrophy Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Vesicle-mediated Transport D-aspartate Transmembrane Transporter Activity	Ubiquitin Conjugating Enzyme Activity Membrane Protein Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Meiotic Nuclear Membrane Microtubule Tethering Complex Protein Ubiquitination Endoplasmic Reticulum Membrane Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation
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