CENPH and NDC80

Number of citations of the paper that reports this interaction (PMID 15713649)
13

Data Source:
BioGRID (two hybrid, two hybrid)

		CENPH	NDC80
Gene Name		centromere protein H	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Kinetochore Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Mitotic Cell Cycle Nucleosome Assembly CENP-A Containing Nucleosome Assembly Kinetochore Assembly Kinetochore Organization	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CENPK KIF2C MTAP NDC80 NUF2	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		64946	10403
HPRD ID		12029	06277
Ensembl ID		ENSG00000153044	ENSG00000080986
Uniprot IDs		B3KVZ3 Q9H3R5	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Cycle Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Mitotic Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Chromosome Organization Cell Cycle Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Purine Ribonucleoside Salvage Organelle Organization L-methionine Biosynthetic Process From Methylthioadenosine Establishment Of Organelle Localization Microtubule Depolymerization L-methionine Salvage Attachment Of Spindle Microtubules To Kinetochore Organelle Localization Microtubule Cytoskeleton Organization Methionine Biosynthetic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Purine-containing Compound Salvage CENP-A Containing Nucleosome Assembly Mitotic Metaphase Plate Congression Polyamine Metabolic Process Metaphase Plate Congression Histone Exchange DNA Replication-independent Nucleosome Assembly Response To Testosterone Establishment Of Mitotic Spindle Orientation Microtubule Polymerization Or Depolymerization Mitotic Spindle Organization Sulfur Amino Acid Metabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Establishment Of Chromosome Localization Microtubule-based Process Centromere Complex Assembly Spindle Localization Microtubule Anchoring ATP-dependent Chromatin Remodeling Regulation Of Chromosome Segregation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		angptl2 bik blast blasts candidate causative commercial cytopenia dysplasia epigenetic excess focusing gstm5 hypermethylation mapped methylated methylation modalities multilineage networks pairs preleukemic promoters raeb rcmd refractory rerg silencing transforms	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		angptl2 bik blast blasts candidate causative commercial cytopenia dysplasia epigenetic excess focusing gstm5 hypermethylation mapped methylated methylation modalities multilineage networks pairs preleukemic promoters raeb rcmd refractory rerg silencing transforms	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?