SIM2 and ARNT

Number of citations of the paper that reports this interaction (PMID 9271372)
17

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro, two hybrid)

		SIM2	ARNT
Gene Name		single-minded family bHLH transcription factor 2	aryl hydrocarbon receptor nuclear translocator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Aryl Hydrocarbon Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Enhancer Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Positive Regulation Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS			Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552) Urate levels ( 23263486)
Protein-Protein Interactions		3 interactors: ARNT ARNT2 PARK2	37 interactors: ADH5 AHR AHRR AIP ARNT2 BRCA1 CSNK2A1 DIABLO EP300 EPAS1 ESR1 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HIF1A IRAK4 LSM8 MTA3 NCOA1 NCOA2 NCOA7 NCOR2 NPAS4 PML PTGES3 SENP6 SIM1 SIM2 SMAD9 SP1 SRC STRBP TNFAIP1 TRIP11 UBE2I
Entrez ID		6493	405
HPRD ID		02935	00524
Ensembl ID		ENSG00000159263	ENSG00000143437
Uniprot IDs		Q14190	A8K6P0 B0AZM1 F8WAP6 P27540
PDB IDs			1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Linear Polyubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Transcription, DNA-templated Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death RNA Biosynthetic Process Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Positive Regulation Of Cellular Metabolic Process Dopamine Transport In Utero Embryonic Development Positive Regulation Of Hormone Biosynthetic Process Aggresome Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Positive Regulation Of Protein Sumoylation Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic MRNA Transcription Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Tube Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Signaling Intracellular Receptor Signaling Pathway Embryonic Placenta Development Cell Communication Reproductive Structure Development Response To Stimulus Negative Regulation Of Biosynthetic Process Reproductive System Development Regulation Of Cellular Process Embryo Development Organ Development Single Organism Reproductive Process Multicellular Organismal Development
Tagcloud ?		clathrin cns colocalized confocal critical deficits ds elusive endocytosis exacerbates exact hybrid immunoprecipitation interacted laser learning mad2b mediate microscopy minded mitotic nervous neurons overexpression pathophysiological scanning thereby thought transferrin	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Difference) ?		clathrin cns colocalized confocal critical deficits ds elusive endocytosis exacerbates exact hybrid immunoprecipitation interacted laser learning mad2b mediate microscopy minded mitotic nervous neurons overexpression pathophysiological scanning thereby thought transferrin	belong bhlh cobalt confers dimerizes frame helix heterodimer heterodimeric heterologous hif1alpha hif2alpha hif3alpha hifs hrd1 hre hypoxia identity pas prototype reading recognizes resultant shares superfamily tacgtg tension thymus transfections
Tagcloud (Intersection) ?