RUSC2 and DLST

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUSC2	DLST
Description		RUN and SH3 domain containing 2	dihydrolipoamide S-succinyltransferase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Extracellular Exosome	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex
	Molecular Function	Protein Binding Small GTPase Binding	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process		Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
Pathways			Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA
Drugs
Diseases
GWAS		Psoriasis ( 25903422)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		11 interacting genes: DLST EGFR FXR1 GIT2 GOLGA2 KHDRBS1 KLC2 MAGEC1 RAB1A RAB1B SRPRA	21 interacting genes: ARIH2 CCDC86 DLG5 FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1
Entrez ID		9853	1743
HPRD ID		18009	00520
Ensembl ID		ENSG00000198853	ENSG00000119689
Uniprot IDs		Q8N2Y8	B7Z6J1 P36957
PDB IDs		6IF2	6H05
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Metabolic Process Virion Assembly Cadherin Binding Establishment Of Endothelial Intestinal Barrier Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Establishment Of Endothelial Barrier Endothelial Cell Development Dihydrolipoyllysine-residue Succinyltransferase Activity Multivesicular Body, Internal Vesicle Lumen Grb2-Sos Complex Kinesin I Complex Golgi Membrane Golgi Vesicle Transport Establishment Of Protein Localization Organelle Assembly G Protein Activity GTPase Activity Shc-EGFR Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxoadipate Dehydrogenase Complex Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Catabolic Process Epidermal Growth Factor Receptor Activity Autophagosome Assembly GTP Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Autophagosome Organization L-lysine Catabolic Process Membrane Epidermal Growth Factor Binding Positive Regulation Of Protein Glycosylation Establishment Of Localization In Cell Signal Recognition Particle Receptor Complex
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