SHOX2 and CBR3

Data Source: HiPPIP (Novel)

		SHOX2	CBR3
Name		SHOX homeobox 2	carbonyl reductase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Regulation Of Heart Rate Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Chondrocyte Development Sinoatrial Node Development Heart Valve Development Sinoatrial Valve Development Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Digestive Tract Morphogenesis Embryonic Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Axonogenesis Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Muscle Tissue Morphogenesis Cardiac Pacemaker Cell Differentiation Sinoatrial Node Cell Development Stem Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Stem Cell Proliferation	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		None	Phase I - Functionalization of compounds
GWAS		Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 ) Chronotype ( 30696823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Height ( 23563607 25429064 31562340 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Lung cancer in never smokers ( 28604730 ) Monobrow ( 27182965 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Pulse pressure ( 30224653 )	Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )
Novel Interactors		2 novel interactors: CBR3 KDR	10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2
Interacting Genes		3 interacting genes: CDK4 TRIM29 ZDHHC17	7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC
Entrez ID		6474	874
HPRD ID		03936	07222
Ensembl ID		ENSG00000168779	ENSG00000159231
Uniprot IDs		O60902	O75828 V9HW40
PDB IDs		Not available	2HRB
GO Terms Enriched among Interactors		Phylloquinone Catabolic Process 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity NADPH Dehydrogenase (quinone) Activity Vitamin K Catabolic Process Cyclin D2-CDK4 Complex Cyclin D1-CDK4 Complex Cellular Response To Ionomycin Cyclin D3-CDK4 Complex Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sorting Endosome Post-embryonic Camera-type Eye Morphogenesis Endocardium Development Vascular Endothelial Growth Factor Binding Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Vitamin K Metabolic Process Cellular Response To Ether Regulation Of Type B Pancreatic Cell Proliferation Response To Phorbol 13-acetate 12-myristate Cellular Response To Phorbol 13-acetate 12-myristate Lymph Vessel Development Positive Regulation Of Membrane Depolarization Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Nitric Oxide Mediated Signal Transduction Endothelium Development Vascular Wound Healing Positive Regulation Of Vasculogenesis Positive Regulation Of Mitochondrial Depolarization Regulation Of CGMP-mediated Signaling Regulation Of Bone Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Golgi-associated Vesicle Membrane Ketone Catabolic Process NADPH Binding Regulation Of Epithelial Cell Proliferation	Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite